Results 161 to 170 of about 5,342,130 (395)
Pharmacokinetics Simulations for Studying Correlates of Prevention Efficacy of Passive HIV-1 Antibody Prophylaxis in the Antibody Mediated Prevention (AMP) Study [PDF]
arXiv, 2018 A key objective in two phase 2b AMP clinical trials of VRC01 is to evaluate whether drug concentration over time, as estimated by non-linear mixed effects pharmacokinetics (PK) models, is associated with HIV infection rate. We conducted a simulation study of marker sampling designs, and evaluated the effect of study adherence and sub-cohort sample size
arxiv
Hepatitis-C Virus Infection among Injecting Drug Users in Lahore, Pakistan: A Descriptive and Analytical Cross Sectional Study [PDF]
, 1969 Abdul Majeed Akhtar +4 more
openalex +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
International Journal of Preventive Medicine, 2019 Background: This study aimed to examine nurses' job stress based on Karasek's demand-control-support model and assess its relationship with different aspects of fatigue.
Hamed Jalilian +4 more
doaj +1 more source
The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size. [PDF]
, 1979 Jerome L. Knittle +4 more
openalex +1 more source
Measuring Security Price Performance Using Chilean Daily Stock Returns: The Event Study Method [PDF]
Following the Brown-Warner simulation approach and using Chilean daily security returns data, we examine the specification and power of three parametric t-tests commonly used in event-studies: the standardized, the cross-sectional and the porfolio t-test.
Eduardo Sandoval, Rodrigo Saens
core
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
Association between anger management and cigarette consumption in adolescents
Revista de la Facultad de Medicina, 2016 Introduction: Cigarette smoking in adolescents is associated with a set of variables such as sex, age, anxiety disorders, depression and secondhand smoke (parents, siblings and friends). However, the association between anger management and smoking among
Zuleima Cogollo-Milanés +1 more
doaj +1 more source
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei +6 more
wiley +1 more source