Results 111 to 120 of about 6,592,407 (383)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Parental modelling, media equipment and screen-viewing among young children : cross-sectional study [PDF]

open access: yes, 2013
Objective: To examine whether parental screenviewing, parental attitudes or access to media equipment were associated with the screen-viewing of 6-year-old to 8-year-old children. Design: Cross-sectional survey. Setting: Online survey. Main outcome:
Bentley, Georgina F.   +7 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Menstrual Patterns Among School Going Adolescent Girls in Chandigarh and Rural Areas Of Himachal Pradesh, North India

open access: yesNational Journal of Community Medicine, 2015
Background: Menstrual disorders are common among adolescent girls and they are lacking scientific knowledge regarding menstrua- tion and puberty making them more vulnerable.
Dinesh Kumar Walia   +3 more
doaj  

Panels with Nonstationary Multifactor Error Structures [PDF]

open access: yes, 2006
The presence of cross-sectionally correlated error terms invalidates much inferential theory of panel data models. Recent work by Pesaran (2006) suggests a method which makes use of cross-sectional averages to provide valid inference for stationary panel
Kapetanios, George   +2 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prevalence of accidents in individuals under 20 years old in Yazd, Iran

open access: yesPayesh, 2002
Objective {s): To determine type and rate of accidents in individuals under 20 years old in Yazd city. Material & Methods: In this descriptive and cross-sectional study, data gathered by a questionnaire and interview with mothers.
Mazloumi S, Fallah Zadeh H
doaj  

Antibiotics prescribing practices in oral implantology among jordanian dentists. A cross sectional, observational study

open access: yesBMC Research Notes, 2011
Background In oral implantology, there is no consensus on the most appropriate regimen for antibiotics prescribing, the decision to prescribe antibiotic is usually based on procedure, patient and clinician related factors.
Hamdan Ahmad AS   +7 more
doaj   +1 more source

Sex-specific-differences in cardiovascular risk in type-1-diabetes : a cross sectional study [PDF]

open access: yes, 2013
Background: Little is known about the impact of sex-specific differences in the management of type 1 diabetes (T1DM). Thus, we evaluated the influence of gender on risk factors, complications, clinical care and adherence in patients with T1DM.
Hinstersteiner, Juliane   +7 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

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