Results 141 to 150 of about 935,295 (306)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Frontiers in Political ScienceIntroductionReinvestigating the S-curve phenomena at the industry level provides deeper insights about industry-specific trade dynamics, at aggregate-level analysis often complicates.
Riaz Ahmad +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
The correlation between high temperature and cognitive function: a CHARLS 2018 cross-sectional study
Archives of Public HealthBackground Extreme temperature-related events can have a negative impact on the health of populations, especially the elderly. However, there is a lack of research on the relationship between heat exposure and cognitive function in older adults.
Lu-shi Kong +5 more
doaj +1 more source
A Nonparametric Regularization for Spectrum Estimation of Time-Varying Output-Only Measurements
VibrationIn this work, an advanced 2D nonparametric correlogram method is presented to cope with output-only measurements of linear (slow) time-varying systems. The proposed method is a novel generalization of the kernel function-based regularization techniques ...
Péter Zoltán Csurcsia +2 more
doaj +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
AN EXHAUSTIVE COEFFICIENT OF RANK CORRELATION [PDF]
Rank association is a fundamental tool for expressing dependence in cases in which data are arranged in order. Measures of rank correlation have been accumulated in several contexts for more than a century and we were able to cite more than thirty of ...
Rosetta Lombardo, Agostino Tarsitano
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source