Results 201 to 210 of about 935,295 (306)

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration. [PDF]

Aging Cell
Liu L, Lai Y, Tian C, Huang Y, Hao J, Zhao Y, Chen D, Wu T, Zhou D, Zheng X, Yang H, Yu Z, Li N, Yang J.   +13 more
europepmc   +1 more source

Methodological refinement of the submillimeter galaxy magnification bias. Paper 0: cross-correlation function measurements

The measurement of the cross-correlation function is crucial to assess magnification bias in galaxy surveys. Previous works used mini-tile subsampling, but accurately determining the integral constraint (IC) correction for unbiased estimation is ...
Bonavera, L., González-Nuevo, J., Cueli, M. M., Casas, J. M., Crespo, D.   +4 more
core  

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Individualized structure-function coupling reveals behavioral signatures in the adolescent brain. [PDF]

Imaging Neurosci (Camb)
Jafrasteh B, Wang Y, Hu Q, Jamison K, Kuceyeski A, Zhao Q.   +5 more
europepmc   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Reduced Coupling of Global Brain Activity and Cerebrospinal Fluid Flow in Individuals With Betel Quid Dependence. [PDF]

Addict Biol
Fu LL, Lv CQ, Liu LT, Fu QQ, Huang WY, Guo YH, Liu T, Chen HJ, Chen F.   +8 more
europepmc   +1 more source

Notes on Estimation of Cross Correlation Function between two Time Series

The purpose of this paper is discussing the estimation of cross correlation function between two time series, for instance, the monthly mean temperature deviations and monthly average CO2 levels.
Tanaka, Minoru
core  

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

REM sleep proportion: an independent predictor of olfactory dysfunction in obstructive sleep apnea hypopnea syndrome. [PDF]

Front Neurol
Li Y, Huang R, Li X, Pan Q.
europepmc   +1 more source