Results 201 to 210 of about 3,845,111 (305)

Spatio-temporal field, landscape and meteorological datasets describing bruchid beetle populations, grain damage and parasitism in faba bean and lentil fields in France. [PDF]

Data Brief
Herrera C, Bedoussac L, Chery-Lagrange A, Chapelin-Viscardi JD, Tricault Y, Gardarin A.   +5 more
europepmc   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Surgeon Health and Well-Being Initiative: A Survey of General and Orthopedic Surgery Residents' Reports of Musculoskeletal Pain. [PDF]

Cureus
Mohamed M, Kim GJ, Conrad-Schnetz K, Yang Z, Carneval M.   +4 more
europepmc   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

Reliability of computational versus noncomputational metrics of working memory and episodic memory in serious mental illness. [PDF]

J Psychopathol Clin Sci
Winsler K, Barch DM, Boudewyn MA, Carter CS, Erickson MA, Frank MJ, Gold JM, MacDonald AW, Ragland JD, Silverstein SM, Yonelinas AP, Luck SJ.   +11 more
europepmc   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

The Children's Urgent Reduction of Forearm Fractures in the Emergency Department (CURFFED) project : a national prospective trainee-led collaborative audit of practice. [PDF]

Bone Jt Open
Gourbault LJ, Whitham R, Womersley A, Jones E, Christie A, Duggleby L, Atherton WG, CURFFED Collaborative, Doughty B, Smith I, Hassan AR, Levitt W, Davies A, Carpenter C, Saltanat S, Buddhdev P, Lennox-Warburton H, Donnelly E, Kim K, Farooq J, Dean CS, Edwards C, Mahmoud M, Stone A, Oyekan A, Jalgaonkar A, To C, Hunt A, Garner M, Campion A, Sison M, Irby S, Price M, Sharoff L, Worley R, Tahir H, Bircher A, Modi N, Theobald E, Genena A, Carter D, Milnes L, Roberts T, Vasudev A, Green D, Boucher A, Caruana E, Khokhar O, Kumar P, Rahman H, Seewoonarain S, Thumbadoo R, Forster S, Vadivelu R, Bagshaw L, Varghese B, Thalanki S, Franco AC, Hamid L, Liew I, Robinson J, Gurung I, Figg P, Moverley R, Neal-Smith G, Barot K, Oo TP, Hanger J, Larsen M, Jones A, Lougher L, Flintoft-Burt M, Dellis S, Kamal T, Bajaj S, Chema K, Lebe M, Bhandari G, Jeans E, James K, Barrow T, Fernandez L, Razemba T, Hawkins R, Anderson K, Tillotson L, Thomas W, Burden E, Kadambande S, Ibrahim IK, O'Boyle M, McCormack L, O'Donnell J, Baird E, MacDonald F, Aithie J, Robinson P, Esland J, Keightley A, Jain A, Thakker D, Nayak M, Caamina L, Barrow T, Discalicau D, Lockton Z, Burgan A, Morris G, Bansal R, Sinha M, Mostafa O, Ishaq U, Elmorsy A, Thomas A, Ross P, Theivendran K, Khaleeq T, Lindisfarne E, Gangadharan R, Thiruchandran G, Youssef K, Tober A, Shah N, Varasteh A, Bajracharya A, Lashin A, Mifsud M, Lloyd T, Kirk C, Ball T, Sheen J, Kapoor S, Jones IT, Donnachie D, Clamp K, Westacott D, Miller J, Hedge E, Gomindes A, Amour L, Ibrahim J, Dwyer J, Bickley M, Fulcher E, Chourasia AK, Hosny S, Hashem M, Dutta A, Leong D, Fergurson K, Haddock A, Malik M, Varasteh A, Cruz L, Jenkins L, East J, Oxley C.   +156 more
europepmc   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Urban nature-based solutions as public-health infrastructure: a scoping review of implemented interventions. [PDF]

Naturwissenschaften
Kalpakidis D, Efthimiou G, Skanavis C, Papadas IΤ.   +3 more
europepmc   +1 more source