RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Recurrence Plot Based Measures of Complexity and its Application to Heart Rate Variability Data
The knowledge of transitions between regular, laminar or chaotic behavior is essential to understand the underlying mechanisms behind complex systems. While several linear approaches are often insufficient to describe such processes, there are several ...
A. Hempelmann +34 more
core +1 more source
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Schizophrenia is a serious mental disorder. Network analysis of magnetoencephalogram signals may help to identify potential biomarkers of schizophrenia.
Dengxuan Bai +3 more
doaj +1 more source
Research into the formation of a soccer curriculum in early childhood education Through the action research with students belonging to IPU’s soccer club and nursery school children [PDF]
This six-month research examined the influence of playing soccer on the mental and physical development of 5 year old nursery school children under the corporation of students from IPU’s soccer club.
今泉 岳雄 +4 more
core +1 more source
Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. [PDF]
Expression of the oncogenic transcription factor MYC is disproportionately elevated in triple-negative breast cancer (TNBC), as compared to estrogen receptor-, progesterone receptor- or human epidermal growth factor 2 receptor-positive (RP) breast cancer.
Anderton, Brittany +11 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Exploration of PET and MRI radiomic features for decoding breast cancer phenotypes and prognosis. [PDF]
Radiomics is an emerging technology for imaging biomarker discovery and disease-specific personalized treatment management. This paper aims to determine the benefit of using multi-modality radiomics data from PET and MR images in the characterization ...
Arasu, Vignesh A +13 more
core
We present here two promising techniques for the application of the complex network approach to continuous spatio-temporal systems that have been developed in the last decade and show large potential for future application and development of complex ...
Kurths, Jürgen, Marwan, Norbert
core +1 more source
Computational fluid dynamics modeling of symptomatic intracranial atherosclerosis may predict risk of stroke recurrence. [PDF]
BackgroundPatients with symptomatic intracranial atherosclerosis (ICAS) of ≥ 70% luminal stenosis are at high risk of stroke recurrence. We aimed to evaluate the relationships between hemodynamics of ICAS revealed by computational fluid dynamics (CFD ...
Chen, Xiangyan +13 more
core +3 more sources

