Results 71 to 80 of about 79,785 (278)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Phase Synchronization Operator for On-Chip Brain Functional Connectivity Computation [PDF]

, 2019
This paper presents an integer-based digital processor for the calculation of phase synchronization between two neural signals. It is based on the measurement of time periods between two consecutive minima.
Delgado Restituto, Manuel, Rodríguez Vázquez, Ángel Benito, Romaine, James Brian   +2 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Assessing Hydrograph Similarity and Rare Runoff Dynamics by Cross Recurrence Plots

Water Resources Research, 2019
This paper introduces a novel measure to assess similarity between event hydrographs. It is based on cross recurrence plots (CRP) and recurrence quantification analysis (RQA), which have recently gained attention in a range of disciplines when dealing ...
Dadiyorto Wendi, Bruno Merz, Norbert Marwan   +2 more
doaj   +1 more source

Exploring the movement dynamics of deception [PDF]

, 2013
Both the science and the everyday practice of detecting a lie rest on the same assumption: hidden cognitive states that the liar would like to remain hidden nevertheless influence observable behavior. This assumption has good evidence.
Dale, Rick, Duran, Nicholas D., Kello, Christopher T., Richardson, Daniel C., Street, Chris N. H.   +4 more
core   +3 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Nonlinear analysis of bivariate data with cross recurrence plots

, 2002
We use the extension of the method of recurrence plots to cross recurrence plots (CRP) which enables a nonlinear analysis of bivariate data. To quantify CRPs, we develop further three measures of complexity mainly basing on diagonal structures in CRPs ...
Abarbanel, Argyris, Casdagli, Choi, Eckmann, Jürgen Kurths, Kantz, Koebbe, Kurths, Lorenz, Mandelbrot, Marwan, Marwan, Norbert Marwan, Schmitz, Schreiber, Takens, Trauth, Trulla, Webber, Wolf, Zbilut, Zbilut   +22 more
core   +4 more sources

Unified functional network and nonlinear time series analysis for complex systems science: The pyunicorn package [PDF]

, 2015
We introduce the \texttt{pyunicorn} (Pythonic unified complex network and recurrence analysis toolbox) open source software package for applying and combining modern methods of data analysis and modeling from complex network theory and nonlinear time ...
Bastian M., Boyan Beronov, Cover T. M., Csárdi G., Erdős P., Henk A. Dijkstra, Jakob Runge, Jobst Heitzig, Jonathan F. Donges, Jürgen Kurths, Kantz H., Liubov Tupikina, Marc Wiedermann, Norbert Marwan, Qing Yi Feng, Reik V. Donner, Schult D. A., Sprott J. C., Subramaniyam N. P., Veronika Stolbova   +19 more
core   +2 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source