Results 81 to 90 of about 728,963 (352)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

VAIM-CFF: a variational autoencoder inverse mapper solution to Compton form factor extraction from deeply virtual exclusive reactions

open access: yesEuropean Physical Journal C: Particles and Fields
We develop a new methodology for extracting Compton form factors (CFFs) from deeply virtual exclusive reactions such as the unpolarized DVCS cross section using a specialized inverse problem solver, a variational autoencoder inverse mapper (VAIM).
Manal Almaeen   +6 more
doaj   +1 more source

Flavor-dependent radiative corrections in coherent elastic neutrino-nucleus scattering

open access: yesJournal of High Energy Physics, 2021
We calculate coherent elastic neutrino-nucleus scattering cross sections on spin-0 nuclei (e.g. 40Ar and 28Si) at energies below 100 MeV within the Standard Model and account for all effects of permille size.
Oleksandr Tomalak   +3 more
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Spin Polarization in γd→ $vec{n}$ n→ p

open access: yesEPJ Web of Conferences, 2012
The study of spin observables is an important and active issue in low energy nuclear physics. In this contribution we report our recent calculation on the γd→ $vec{n}$ n→ p reaction at low photon energies.
Hyun C. H.   +3 more
doaj   +1 more source

Measurement of the tt¯ production cross section in pp collisions at s=8 TeV in dilepton final states containing one τ lepton

open access: yesPhysics Letters B, 2014
The top-quark pair production cross section is measured in final states with one electron or muon and one hadronically decaying τ lepton from the process tt¯→(ℓνℓ)(τντ)bb¯, where ℓ=e,μ. The data sample corresponds to an integrated luminosity of 19.6 fb−1
V. Khachatryan   +2143 more
doaj   +1 more source

Measurement of the scattering cross section of slow neutrons on liquid parahydrogen from neutron transmission [PDF]

open access: yes, 2014
Liquid hydrogen is a dense Bose fluid whose equilibrium properties are both calculable from first principles using various theoretical approaches and of interest for the understanding of a wide range of questions in many-body physics.
K. Grammer   +31 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

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