Results 61 to 70 of about 1,634,188 (245)

A cross‐sectional natural history study of aspartylglucosaminuria

JIMD Reports, 2022
Aspartylglucosaminuria (AGU) is a rare lysosomal storage disorder that causes stagnation of development in adolescence and neurodegeneration in early adulthood.
Kimberly Goodspeed, Daniel Horton, Andrea Lowden, Peter V. Sguigna, Timothy Booth, Zhiyue J. Wang, Veronica Bordes Edgar   +6 more
doaj   +1 more source

Accurate cross sections for microanalysis

Journal of Research of the National Institute of Standards and Technology, 2002
To calculate the intensity of x-ray emission in electron beam microanalysis requires a knowledge of the energy distribution of the electrons in the solid, the energy variation of the ionization cross section of the relevant subshell, the fraction of ionizations events producing x rays of interest and the absorption coefficient of the x rays on the path
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Nurse practitioner work patterns: A cross‐sectional study

Nursing Open, 2021
Aim The aim was to determine how nurse practitioner (NP) roles are translated into clinical practice across Victoria, Australia. This paper reports details about NP work patterns and scopes of practice across multiple clinical settings and geographic ...
Grainne Lowe, Kathleen Tori, Natasha Jennings, Dan Schiftan, Andrea Driscoll   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

(Effect of lifestyle and demographic factors on female sexual function: a survey study in sharkia governorate, Egypt [PDF]

Zagazig University Medical Journal
1- Abstract:Background: Female sexual dysfunction (FSD) is defined as persistent or recurring decrease in sexual desire, sexual arousal, dyspareunia and a difficulty in or inability to achieve an orgasmAim the work: To evaluate the effect of life style ...
esraa abdelwahab, Abdallah Kandil, Mohamed Nasr   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Violence against Women with Disabilities and Mental Health in Gurage Zone, Central Ethiopia: Cross-sectional Study

Jefore Ethiopian Journal of Applied Sciences
Violence against women and girls (VAWG) with disabilities is a public health concern worldwide. This study is aimed at examining the prevalence of VAWG among women and girls with disabilities (WGWD), identifying associated factors, and investigating its
Tekalign Deksissa Bejji, Yadesa Diriba Dugo   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source