Results 51 to 60 of about 2,172,434 (304)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

A Pilot Study on the Effect of Anti-Thrombopoietin Antibody on Platelet Count in Patients with Type 2 Diabetes

open access: yesMolecules, 2020
Thrombopoietin (THPO) is a circulatory cytokine that plays an important role in platelet production. The presence of anti-THPO antibody relates to thrombocytopenia and is rarely seen in hematopoietic and autoimmune diseases.
Takuya Fukuda   +11 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Estimating the prevalence and predictors of musculoskeletal disorders in Tanzania: a cross-sectional pilot study [PDF]

open access: yes
Introduction Musculoskeletal (MSK) disorders account for approximately 20% of all years lived with disability worldwide however studies of MSK disorders in Africa are scarce.
Emma McIntosh   +12 more
core   +1 more source

A Study of Depression Among Aged in Surat City

open access: yesNational Journal of Community Medicine, 2010
This cross-sectional study interviews 105 elderly belonging to different socioeconomic and varying demographic groups of Surat city as per predefined inclusion and exclusion criteria with their informed consent in compliance with 'Ethical principles for
Vishal Jariwala   +3 more
doaj  

Risk Assessment For Clinical Attachment Loss In Periodontitis Patients

open access: yesInternational Dental Journal
Aim or purpose: The purpose of this study was to assess the risk factors of clinical attachment loss (CAL) in periodontitis patients in different dental regions.
Shuo Liu
doaj   +1 more source

Association between frequency of dairy product consumption and hypertension: a cross-sectional study in Zhejiang Province, China

open access: yesNutrition & Metabolism, 2022
Background Hypertension, a well-known risk factor, contributes to millions of deaths from cardiovascular and renal diseases worldwide. However, evidence on the association between frequency of dairy product consumption and hypertension is inconsistent ...
Hao Wang   +10 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Thirdhand Smoke Exposure Ignored by Pediatricians: A Cross-sectional Study

open access: yes
Objective: Thirdhand smoke (THS) is defined as the harmful substances in cigarette smoke that are absorbed into objects, people, and surfaces after smoking.
Emine Kaygı Tartıcı   +2 more
core   +1 more source

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