Results 121 to 130 of about 45,029 (376)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

open access: yesMolecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková   +14 more
wiley   +1 more source

Rotational crossbreeding systems for pork producers (1993) [PDF]

open access: yes, 1993
More than 90 percent of hogs marketed are of mixed breeding, an indication that crossbreeding is a well accepted management program. Yet crossbreeding alone does not guarantee efficient, profitable production. Choosing the system and breeds that fit your
Bates, Ronald Oscar, 1959-
core  

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

open access: yesMolecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides   +13 more
wiley   +1 more source

Conventional and Mixed Model Approach to Estimate Heterosis of the Growth Traits in Boer Goat’s Crossbred Offspring Populations

open access: yesCaraka Tani: Journal of Sustainable Agriculture, 2019
Heterosis is often utilized as a success indicator in a crossbreeding program. It is defined as the deviation of the crossbred means relative to their parental breeds.
Nuzul Widyas   +3 more
doaj   +1 more source

Genetic diversity and selective breeding of red common carps in China [PDF]

open access: yes, 2001
China has a very rich genetic diversity in common carp (Cyprinus carpio) and the red common carp plays an important role in Chinese aquaculture and genetic studies.
Li, S.F., Wang, C.H.
core  

Crossbreeding locally adapted hair sheep to improve productivity and meat quality

open access: yesScientia Agricola, 2018
The use of lambs from crossing of local with specialized sheep breeds for meat production may lead to higher meat deposition and a smaller fat amount in the carcass, with a more adequate nutritional profile for human consumption.
J. Issakowicz   +7 more
semanticscholar   +1 more source

A comparison of three selection systems for crossbreeding

open access: yesJournal of Animal Breeding and Genetics, 1992
SummaryThree selection methods for crossbreeding have been compared, using two different strains of Tribolium castaneum, to investigate possible improvement of half‐sibs virgin females egg weight in both an optimum and a stress environment. It was carried out with eleven generations of each of the following selection systems: Within Strain Selection ...
Serrano Noreña, Magdalena, Orozco, F.
openaire   +4 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

The Breeder’s Eye – Theoretical Aspects of the Breeder’s Decision-Making [PDF]

open access: yes, 2006
The report describes an empirical research project which investigated the peculiarity and role of knowledge gained through experience in plant breeding from the breeder’s perspective.
Timmermann, Martin
core  

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

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