Results 131 to 140 of about 204,167 (264)

Epistasis: Searching for Interacting Genetic Variants Using Crosses

G3: Genes, Genomes, Genetics, 2017
Ian M. Ehrenreich
doaj   +1 more source

Programmed Genome Elimination Is Evolutionarily Conserved Across <i>Pelophylax</i> Hybrids-As Evidenced by <i>P. grafi</i> Hybridogenetic Reproduction. [PDF]

Biology (Basel)
Dudzik A, Rozenblut-Kościsty B, Dedukh D, Crochet PA, Choleva L, Przewłocka-Kosmala M, Stryczak Z, Ogielska M, Chmielewska M.   +8 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Maternal inheritance of primary sex ratios in the dark-winged fungus gnat Lycoriella ingenua. [PDF]

Heredity (Edinb)
Shlyakonova M, Monteith KM, Ross L, Baird RB.   +3 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity. [PDF]

Evolution
Fukutomi Y, Phillips-Garcia A, Liu J, Chuang A, Watada M, Ramniwas S, Kopp A.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Variation in tolerance to heterospecific pollen from a non-native congener depends on co-existence history of maternal and paternal source populations. [PDF]

Am J Bot
Hoshino Y, Horie S, Maki M, Dohzono I.
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Curing Parthenogenesis-Inducing (PI) <i>Wolbachia</i>-Induced Reproductive Disorders in the Egg Parasitoid <i>Telenomus remus</i>. [PDF]

Biology (Basel)
Tu IC, Lai CT, Wu LH.
europepmc   +1 more source