Results 51 to 60 of about 211,650 (268)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Equity trading by institutional investors: To cross or not to cross? [PDF]
Journal of Financial Markets, 2002 The proliferation of market places and trading methods is a striking feature of current equity markets. A stated goal of all the new trading arrangements is to reduce transactions costs. We investigate costs in one new market place, the crossing network.
Ødegaard, Bernt Arne, Næs, Randi
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
CeROArt : Conservation, Exposition, Restauration d'Objets d'Art, 2011 The comparative study of several big wooden crosses painted by Giotto allowed to deepen the work organization in the Middle Ages’ workshop. This analysis found several analogies of execution between the works, by demonstrating that the production of ...
Daphné de Luca
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Revista Brasileira de Zootecnia, 2003 Trinta e seis cordeiros, 12 cruzas Texel x Bergamácia (TB), 12 cruzas Texel x Santa Inês (TS) e 12 puros Santa Inês (SI), foram confinados individualmente, por um período de 50 dias.
Iraides Ferreira Furusho-Garcia +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Moment Crossings as Related to Density Crossings
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1965 Summary In this paper we show how the number of moment crossings of two symmetrical densities is related to the number of crossings of the densities. This generalizes a result of Fisher recently proved by Finucan (1964).
Marsaglia, G. +2 more
openaire +2 more sources
Cross and Learn: Cross-Modal Self-supervision [PDF]
, 2019 GCPR ...
Nawid Sayed +2 more
openaire +2 more sources