Results 101 to 110 of about 801,183 (312)

Age, Sex, and Genetic Architecture of Human Gene Expression in EBV Transformed Cell Lines [PDF]

arXiv, 2009
Individual expression profiles from EBV transformed cell lines are an emerging resource for genomic investigation. In this study we characterize the effects of age, sex, and genetic variation on gene expression by surveying public datasets of such profiles.
arxiv  

Genetics of inbred Drosophila melanogaster VI. Crossing-over in secondary non-disjunction exceptionals [PDF]

Hereditas, 2008
Although Bridges (1916, Genetics 1: 1–52 and 107–183) found recombinants among exceptional XXY females in tests of secondary non-disjunction, he misinterpreted their origin and claimed that true secondary non-disjunction resulted in XX eggs with non-crossover chromosomes.
openaire   +3 more sources

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

An efficient method for markerless mutant generation by allelic exchange in Clostridium acetobutylicum and Clostridium saccharobutylicum using suicide vectors

Biotechnology for Biofuels, 2019
Background Clostridium acetobutylicum and Clostridium saccharobutylicum are Gram-positive, spore-forming, anaerobic bacterium capable of converting various sugars and polysaccharides into solvents (acetone, butanol, and ethanol).
Celine Foulquier, Ching-Ning Huang, Ngoc-Phuong-Thao Nguyen, Axel Thiel, Tom Wilding-Steel, Julie Soula, Minyeong Yoo, Armin Ehrenreich, Isabelle Meynial-Salles, Wolfgang Liebl, Philippe Soucaille   +10 more
doaj   +1 more source

Estimates of genetic parameters and genetic trends for growth, reproduction, milk production and milk composition traits of Awassi sheep.

Animal, 2019
Genetic parameters and genetic trends for growth, reproduction, milk production and composition traits were estimated for Syrian (S) and Turkish (T) Awassi sheep and their crosses maintained at the International Center for Agricultural Research in the ...
A. Haile, M. Hilali, H. Hassen, R. Lôbo, B. Rischkowsky   +4 more
semanticscholar   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Crossing Over…Markov Meets Mendel

PLoS Comput. Biol., 2012
Chromosomal crossover is a biological mechanism to combine parental traits. It is perhaps the first mechanism ever taught in any introductory biology class.
S. Mneimneh
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

DNA repair and crossing over favor similar chromosome regions as discovered in radiation hybrid of Triticum

BMC Genomics, 2012
BackgroundThe uneven distribution of recombination across the length of chromosomes results in inaccurate estimates of genetic to physical distances. In wheat (Triticum aestivum L.) chromosome 3B, it has been estimated that 90% of the cross over events ...
Ajay Kumar, F. Bassi, E. Paux, O. Al-Azzam, Monika Michalak de Jiménez, A. Denton, Y. Gu, E. Huttner, A. Kilian, Sachin Kumar, A. Goyal, M. Iqbal, V. Tiwari, M. Doğramacı, H. Balyan, H. Dhaliwal, P. Gupta, G. S. Randhawa, C. Feuillet, W. Pawlowski, S. Kianian   +20 more
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source