Results 101 to 110 of about 110,448 (258)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Stochastic simulation to optimize rice breeding at IRRI

Frontiers in Plant Science
IntroductionGenetic improvement in rice increased yield potential and improved varieties for farmers over the last decades. However, the demand for rice is growing while its cultivation faces challenges posed by climate change.
Fallou Seck, Fallou Seck, Parthiban Thathapalli Prakash, Giovanny Covarrubias-Pazaran, Tala Gueye, Ibrahima Diédhiou, Sankalp Bhosale, Suresh Kadaru, Jérôme Bartholomé, Jérôme Bartholomé, Jérôme Bartholomé   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genetic Control of Fruit-to-Bean Ratio and Mass-Based Metrics for Processing Efficiency in Coffea canephora

Plants
The expanding use of Conilon and Conilon × Robusta hybrids in Brazilian coffee cultivation contrasts with the scarcity of information on the genetic variability underlying their physical yield attributes.
Jéssica Almeida Jorge, Cleidson Alves da Silva, Deurimar Herênio Gonçalves Júnior, Ivoney Gontijo, Rodrigo Barros Rocha, Eveline Teixeira Caixeta, Weverton Pereira Rodrigues, Fábio Luiz Partelli   +7 more
doaj   +1 more source

ESTIMATION OF GENETIC EFFECTS ON PLANT HEIGHT IN TWO SPECIFIC PAIRS OF INBRED LINES AND ITS SIX BASIC GENERATIONS [PDF]

Poljoprivreda, 2003
Estimation of genetic effects on economically important traits is a common procedure in the most breeding programmes at Agricultural Institute Osijek. This paper deals with estimation of adequacy over additive/dominance model of inheritance as well as ...
Zvonimir Zdunić, Domagoj Šimić, Ivan Brkić, Antun Jambrović, Renata Zdunić, Tatjana Ledenčan   +5 more
doaj  

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Genetic Gain and Inbreeding in Different Simulated Genomic Selection Schemes for Grain Yield and Oil Content in Safflower

Plants
Safflower (Carthamus tinctorius L.) is a multipurpose minor crop consumed by developed and developing nations around the world with limited research funding and genetic resources.
Huanhuan Zhao, Majid Khansefid, Zibei Lin, Matthew J. Hayden   +3 more
doaj   +1 more source