Results 101 to 110 of about 300,493 (300)
Genetics, 1971 ANDLER and NOVITSKI (1957) proposed the term “meiotic drive” (or segregation distortion) to describe a condition which leads to unequal segregation of the two alleles present in a heterozygote in consequence of certain aberrant mechanisms during meiosis.
A S, Mukherjee, A K, Das
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Plant GenomeGenome‐wide introgression and substitution lines have been developed in many plant species, enhancing mapping precision, gene discovery, and the identification and exploitation of variation from wild relatives.
Richard Horsnell +9 more
doaj +1 more source
Genetic Renal Diseases: The Emerging Role of Zebrafish Models
Cells, 2018 The structural and functional similarity of the larval zebrafish pronephros to the human nephron, together with the recent development of easier and more precise techniques to manipulate the zebrafish genome have motivated many researchers to model human
Mohamed A. Elmonem +5 more
doaj +1 more source
Труды по прикладной ботанике, генетике и селекции, 2020 Background. The problem of nucleus-plastid interactions is obviously of theoretical and practical importance. However, the lack of knowledge in this area of plant research is, for the most part, caused by difficulties in isolating the contribution of the
A. V. Usatov +3 more
doaj +1 more source
Glasgow Contributions to the Human Gene Mapping Project, 1959-1987 [PDF]
, 2015 No abstract ...
Ferguson-Smith, Malcolm
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Floral biology and reproductive mechanisms of Mussambê (Cleome spinosa Jacq) aiming at the plant breeding [PDF]
Biotemas, 2007 Some plants from Cleome genus in Capparaceae family are used as medicinal and ornamental plants. The aim of this work was to study the fl oral biology and the reproductive mechanisms of C. spinosa to the plant breeding. Anthesis occurred between 17:30 to
Cláudio Lúcio Fernandes Amaral +2 more
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source