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A crossover study of triptorelin and leuprorelin acetate
Fertility and Sterility, 2000To compare the potency, side effects, and duration of action of triptorelin and leuprorelin acetate after i.m. injections.Prospective, double-blind crossover clinical study.A teaching hospital.Fifty-four patients with pelvic endometriosis.Twenty-seven patients had three doses of i.m. triptorelin (3.75 mg) followed by three doses of i.m.
Tak Hong Cheung +4 more
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Crossover Studies with Binary Responses
2002The two-period crossover trial has the evident advantage that by the use of within-patients comparisons, the usually larger between-patient variability is not used as a measuring stick to compare treatments. However, a prerequisite is that the order of the treatments does not substantially influence the outcome of the treatment.
Aeilko H. Zwinderman +2 more
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Alcohol and injury. A case-crossover study
Archives of Family Medicine, 1995To determine whether and to what extent alcohol consumption increases the risk of injury.The case-crossover study is a new research design for assessing rare acute events (such as trauma) in relation to intermittent exposures (such as alcohol use) that have transient effects.
J Becker +6 more
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Interpretation and bias in case-crossover studies
Journal of Clinical Epidemiology, 1997The case-crossover design is an innovative epidemiologic technique with distinct strengths and limitations. We review the fundamental logic of this self-matching non-randomized design and direct attention to 15 concerns related to the available data, unavailable data, analytic technique, quantitative statistics, and etiologic model.
Robert Tibshirani +2 more
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Crossover and Parallel Study of Oral Analgesics
The Journal of Clinical Pharmacology, 1981Abstract: Ten years ago, analgesics were studied using crossover designs. In recent years, analgesics have been studied only in parallel designs primarily because biostatisticians do not like crossover studies. The advantages of crossover studies are numerous: (1) patients serve as their own control; (2) there is less variability of responses among ...
Richard I. H. Wang, B S Elizabeth Waite
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The analysis of failure time data in crossover studies
Statistics in Medicine, 1990AbstractClinical trials of new drugs in the treatment of angina pectoris frequently make use of exercise tests to evaluate efficacy. The crossover design is often employed. The methods commonly used to analyse the various exercise times, for example, ‘time to pain’, are insensitive and potentially biased by the manner in which they deal with the ...
L A, France, J A, Lewis, R, Kay
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Angled transscleral intravitreal injection: a crossover study
European Journal of Ophthalmology, 2014Purpose The perfect intravitreal injection delivers an exact amount of medication with the least risk to vision and the eye. We examined 2 different methods of intravitreal injection to determine if an angled transscleral entry for intravitreal injection results in less egress of intravitreal contents, including medication.
Mitul C Mehta, Paul T. Finger
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Crossover Studies with Continuous Variables
2011Crossover studies with continuous variables are routinely used in clinical drug research: for example, no less than 22% of the double-blind placebo-controlled hypertension trials in 1993 were accordingly designed (Niemeyer et al. 1998). A major advantage of the crossover design is that it eliminates between-subject variability of symptoms.
Aeilko H. Zwinderman, Ton J. Cleophas
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A Case-Crossover Study of Sleep and Childhood Injury
Pediatrics, 2001Objective.To evaluate the association between sleep and wakefulness duration and childhood unintentional injury.Study Design.Case-crossover study.Methods.Two hundred ninety-two injured children who presented at the Children's Emergency Center of Udine, Italy, or their parents were interviewed after a structured questionnaire.
Silvio Brusaferro +3 more
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Sensory experiments as crossover studies
Food Quality and Preference, 1998Abstract In most sensory studies the products are evaluated one after another. There is concern that the perception of assessors might be influenced by carryover effects. Therefore it might be useful to use a design which is balanced for carryover effects and to not randomize the order in which the products are tasted.
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