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Interpretation and bias in case-crossover studies
Journal of Clinical Epidemiology, 1997The case-crossover design is an innovative epidemiologic technique with distinct strengths and limitations. We review the fundamental logic of this self-matching non-randomized design and direct attention to 15 concerns related to the available data, unavailable data, analytic technique, quantitative statistics, and etiologic model.
D A, Redelmeier, R J, Tibshirani
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Crossover and Parallel Study of Oral Analgesics
The Journal of Clinical Pharmacology, 1981Abstract: Ten years ago, analgesics were studied using crossover designs. In recent years, analgesics have been studied only in parallel designs primarily because biostatisticians do not like crossover studies. The advantages of crossover studies are numerous: (1) patients serve as their own control; (2) there is less variability of responses among ...
R I, Wang, E, Waite
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A preliminary study of crowding with biased crossover
Proceedings of the 15th annual conference companion on Genetic and evolutionary computation, 2013This paper proposes a novel crowding method, which is called "Crowding with Biased Crossover (CBX)". The Biased crossover operator begins with two parents. Then two offspring individuals are created, each offspring taking more characteristics from one of the two parents.
Shigeyoshi Tsutsui, Noriyuki Fujimoto
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Angled transscleral intravitreal injection: a crossover study
European Journal of Ophthalmology, 2014Purpose The perfect intravitreal injection delivers an exact amount of medication with the least risk to vision and the eye. We examined 2 different methods of intravitreal injection to determine if an angled transscleral entry for intravitreal injection results in less egress of intravitreal contents, including
Mitul C, Mehta, Paul T, Finger
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Crossover Studies with Continuous Variables: Power Analysis
American Journal of Therapeutics, 2002The crossover design is a sensitive means of determining the efficacy of new drugs because it eliminates between-subject variability. However, if the response in the first period carries on into the second (carryover effect) or if time factors cannot be kept constant in a lengthy crossover (time effects), its statistical power may be jeopardized.
Cleophas, T. J. M., Zwinderman, A. H.
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Testing Crossover Studies for Carryover Effects
Angiology, 1989For the study of cardiovascular disease, for instance, hypertension and angina pectoris, properly de signed crossover studies are to be preferred over parallel-design stud ies. Many statisticians now propose that these studies should always be tested for carryover effects.
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A Case-Crossover Study of Sleep and Childhood Injury
Pediatrics, 2001Objective.To evaluate the association between sleep and wakefulness duration and childhood unintentional injury.Study Design.Case-crossover study.Methods.Two hundred ninety-two injured children who presented at the Children's Emergency Center of Udine, Italy, or their parents were interviewed after a structured questionnaire.
VALENT, Francesca +2 more
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A study of crossover operators in genetic programming
1991Holland's analysis of the sources of power of genetic algorithms has served as guidance for the applications of genetic algorithms for more than 15 years. The technique of applying a recombination operator (crossover) to a population of individuals is a key to that power. Neverless, there have been a number of contradictory results concerning crossover
William M. Spears, Vic Anand
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STUDY IN CROSSOVER FRIES MIGRATION
Organic Preparations and Procedures International, 1992(1992). STUDY IN CROSSOVER FRIES MIGRATION. Organic Preparations and Procedures International: Vol. 24, No. 6, pp. 687-690.
R. N. Khanna +2 more
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