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A crossover pill study among Sudanese women
International Journal of Gynecology & Obstetrics, 1985A crossover study from a standard-dose to a low-dose oral contraceptive was conducted in the Sudan. Reported side effects were very few, with a headache the most frequently reported. Switching to the other pill did not affect the rate of any side effects.
A S, Gerais, H, Rushwan
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Interpretation and bias in case-crossover studies
Journal of Clinical Epidemiology, 1997The case-crossover design is an innovative epidemiologic technique with distinct strengths and limitations. We review the fundamental logic of this self-matching non-randomized design and direct attention to 15 concerns related to the available data, unavailable data, analytic technique, quantitative statistics, and etiologic model.
D A, Redelmeier, R J, Tibshirani
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Crossover Studies with Binary Responses
2011The two-period crossover trial has the evident advantage that by the use of within-patients comparisons, the usually larger between-patient variability is not used as a measuring stick to compare treatments. However, a prerequisite is that the order of the treatments does not substantially influence the outcome of the treatment.
Ton J. Cleophas, Aeilko H. Zwinderman
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Crossover Studies with Continuous Variables
2011Crossover studies with continuous variables are routinely used in clinical drug research: for example, no less than 22% of the double-blind placebo-controlled hypertension trials in 1993 were accordingly designed (Niemeyer et al. 1998). A major advantage of the crossover design is that it eliminates between-subject variability of symptoms.
Ton J. Cleophas, Aeilko H. Zwinderman
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Alcohol and injury. A case-crossover study
Archives of Family Medicine, 1995To determine whether and to what extent alcohol consumption increases the risk of injury.The case-crossover study is a new research design for assessing rare acute events (such as trauma) in relation to intermittent exposures (such as alcohol use) that have transient effects.
D C, Vinson +6 more
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[Occupational backache: crossover study].
Giornale italiano di medicina del lavoro ed ergonomia, 2008The authors briefly review the risk factors for the spine involved in working activities. Three hundred workers doing different jobs were studied for their general physical condition, job-related postures, the site of any back pain, and motor activity practiced.
P, Raimondi, V, Prosperini, M, Hendel
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Crossover and Parallel Study of Oral Analgesics
The Journal of Clinical Pharmacology, 1981Abstract: Ten years ago, analgesics were studied using crossover designs. In recent years, analgesics have been studied only in parallel designs primarily because biostatisticians do not like crossover studies. The advantages of crossover studies are numerous: (1) patients serve as their own control; (2) there is less variability of responses among ...
R I, Wang, E, Waite
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Cephaloglycin: Crossover absorption studies and clinical evaluation
Clinical Pharmacology & Therapeutics, 1969Studies with volunteers on oral administration of cephaloglycin resulted in low serum but higher urinary concentrations. Although some absorption was observed with orally administered cephaloridine, serum levels were shorter in duration and urine concentrations were lower than those observed with cephaloglycin.
R L, Perkins, G E, Glontz, S, Saslaw
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Sensory experiments as crossover studies
Food Quality and Preference, 1998Abstract In most sensory studies the products are evaluated one after another. There is concern that the perception of assessors might be influenced by carryover effects. Therefore it might be useful to use a design which is balanced for carryover effects and to not randomize the order in which the products are tasted.
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