Results 161 to 170 of about 3,843,339 (249)

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao   +2 more
wiley   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

open access: yesAdvanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao   +15 more
wiley   +1 more source

Improving crowdsourcing for AI through cognitive-inspired data engineering. [PDF]

open access: yesBehav Res Methods
Epping GP   +5 more
europepmc   +1 more source

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

open access: yesAdvanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang   +6 more
wiley   +1 more source

Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content

open access: yesAdvanced Science, EarlyView.
Raman hyperspectral imaging combined with spectral phasor analysis enables a label‐free quantification of proteins, polymers and water density within individual biomolecular condensates. By transforming complex vibrational fingerprints into intuitive compositional maps, the approach reveals the high water content and structural heterogeneity of ...
E. Sabri   +3 more
wiley   +1 more source

Self‐Healing Ionogel Dual‐Network Enables Synergistic Defect Passivation and Strain Relief for High‐Efficiency Robust Perovskite Photovoltaics

open access: yesAdvanced Science, EarlyView.
PSCs are afflicted by inherent defects and lattice strain that limit PCE and stability. A cross‐linked multifunctional ionogel [HA‐AA][EMIES] is developed to modulate crystallization, relieve residual strain, and passivate defects, extending carrier diffusion length to over 8 µm and delivering PCEs of 26.45% for rigid devices and 25.14% for flexible ...
Wen Wu   +12 more
wiley   +1 more source

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