Results 41 to 50 of about 152,888 (302)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
When crowding of crowding leads to uncrowding
Journal of Vision, 2013 In object recognition, features are thought to be processed in a hierarchical fashion from low-level analysis (edges and lines) to complex figural processing (shapes and objects). Here, we show that figural processing determines low-level processing. Vernier offset discrimination strongly deteriorated when we embedded a vernier in a square.
Manassi Mauro +2 more
openaire +5 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Netherlands Heart Journal, 2014 QuestionA 40-year-old woman was seen at our outpatient clinicbecause of episodes of palpitations that lasted severalhours. She reported no syncopal episodes or familyhistory of sudden cardiac death and was not on anymedication. The resting ECG and ECG recorded duringthe palpitations are shown in Fig. 1a and b.Whatisthe(differential) diagnosis?AnswerYou
Lahrouchi, N. +2 more
openaire +4 more sources
Visual Aspects of Reading Performance in Myalgic Encephalomyelitis (ME)
Frontiers in Psychology, 2018 People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) report vision-related reading difficulty, although this has not been demonstrated objectively.
Rachel L. Wilson +3 more
doaj +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
FEBS Letters, EarlyView.Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Crowded environments tune the fold-switching in metamorphic proteins
Communications Chemistry, 2023 Metamorphic proteins such as circadian clock protein KaiB and human chemokine XCL1 play vital roles in regulating biological processes, including gene expression, circadian clock and innate immune responses, and perform distinct functions in living cell ...
Ning Zhang +3 more
doaj +1 more source
Enforced Stacking in Crowded Arenes
, 2016 Enforced Stacking in Crowded ...
Colin Nuckolls (1321299) +3 more
core +1 more source