Results 51 to 60 of about 63,605 (264)

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Professional judgment of an accountant in the valuation of hybrid instruments in the reporting of controlled foreign companies

Економіка, управління та адміністрування
The modern taxation system of controlled foreign companies (CFCs) in Ukraine requires accountants to shift from mechanical accounting to analyzing the economic essence of operations. The use of hybrid financial instruments creates risks of mismatches due
I.V. Zhyhlei
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Human Leukocyte Antigen E Contributes to Protect Tumor Cells from Lysis by Natural Killer Cells

Neoplasia: An International Journal for Oncology Research, 2011
The nonclassic class I human leukocyte antigen E (HLA-E) molecule engages the inhibitory NKG2A receptor on several cytotoxic effectors, including natural killer (NK) cells.
Elisa Lo Monaco, Elisa Tremante, Cristina Cerboni, Elisa Melucci, Leonardo Sibilio, Alessandra Zingoni, Maria Rita Nicotra, Pier Giorgio Natali, Patrizio Giacomini   +8 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

IDENTIFICAÇÃO DAS ÁREAS SUSCEPTÍVEIS A TRANSFERÊNCIA DE POLUENTES PARA OS SISTEMAS AQUÁTICOS UTILIZANDO ÁLGEBRA DE MAPAS

Caminhos de Geografia, 2017
Este trabalho objetivou gerar um mapa de susceptibilidade a transferência de poluentes para os sistemas aquáticos em um município com suinocultura intensiva utilizando informações cartográficas, sensoriamento remoto e legislação ambiental.
Viviane Capoane, Luis Fernando Flenik Costa, Tatiana Mora Kuplich   +2 more
doaj  

Use of a Nutrition Behavior Change Counseling Tool: Lessons from a Rapid Qualitative Assessment in Eastern Zambia

Frontiers in Public Health, 2016
The U.S. Agency for International Development Feed the Future Mawa Project—led by Catholic Relief Services—aims to improve food and economic security for farming households in Zambia’s Eastern Province.
Ingrid M Weiss, Serena Stepanovic, Ulembe Chinyemba, Jessica Bateman, Carolyn Hemminger, Emily Burrows   +5 more
doaj   +1 more source