Reported problems and responses during the conduct of stepped-wedge cluster randomized trials in healthcare settings: a qualitative systematic review. [PDF]
Int J EpidemiolTaylor KS +7 more
europepmc +1 more source
Boost Approaches in Patients Undergoing Postoperative Radiotherapy
Journal of Surgical Oncology, EarlyView.ABSTRACT The use of breast conservation surgery for early‐stage breast cancer is common, and adjuvant radiotherapy is often recommended to reduce the risk of ipsilateral breast tumor recurrence. Historical trials have used sequential boost techniques with favorable outcomes with reduction in local recurrence and acceptable cosmetic outcomes.
Abigail Pepin +5 more
wiley +1 more source
Practical inference for a complier average causal effect in cluster randomised trials with a binary outcome. [PDF]
Clin TrialsEdwards T +3 more
europepmc +1 more source
Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis
The Laryngoscope, EarlyView.This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua +3 more
wiley +1 more source
Different types of cluster membership in parallel-group cluster-randomised trials, where the clusters are institutions: a classification system to aid identification, with six proposed designs. [PDF]
TrialsMarsden LE +5 more
europepmc +1 more source
Radiotherapy and Immune System Interactions Historical Perspectives and Clinical Advancements
Molecular Carcinogenesis, EarlyView.ABSTRACT Radiotherapy (RT) has evolved significantly since its inception from treating benign conditions to becoming a cornerstone of cancer treatment. This review examines the complex interactions between RT and the immune system, highlighting its diverse effects on various immune cell populations, and exploring emerging strategies to enhance ...
Safiy Yahia +3 more
wiley +1 more source
Preference-Informed Cluster Randomized Design for Pragmatic Clinical Trials. [PDF]
Stat MedCheng Y, Tremoulet A, Jain S.
europepmc +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objectives Evaluate the association of plating strategies with hardware removal and operative time, after adjusting for relevant clinical variables. Study Design Retrospective Review. Setting Multiple Academic Medical Centers. Methods Patients undergoing osseous free flap reconstruction stratified based on the plating strategy [conventional ...
Craig A. Bollig +19 more
wiley +1 more source
Pediatric Investigation, EarlyView.The combination of cardiac resynchronization therapy and pulmonary artery banding was associated with substantial improvement in advanced heart failure infants with left ventricular dilated cardiomyopathy and left bundle branch block. Most patients exhibited marked improvement in clinical status and ventricular function, along with a reduction in QRS ...
Min Zeng +8 more
wiley +1 more source