Results 61 to 70 of about 14,964 (269)

Genomic organization of the structural genes controlling the astaxanthin biosynthesis pathway of Xanthophyllomyces dendrorhous

Biological Research, 2008
The cloning and nucleotide sequence of the genes (idi, crtE, crtYB, crtl and crtS) controlling the astaxanthin biosynthesis pathway of the wild-type ATCC 24230 strain of Xanthophyllomyces dendrorhous in their genomic and cDNA version were obtained.
MAURICIO NIKLITSCHEK, JENNIFER ALCAÍNO, SALVADOR BARAHONA, DIONISIA SEPÚLVEDA, CARLA LOZANO, MARISELA CARMONA, ANDRÉS MARCOLETA, CLAUDIO MARTÍNEZ, PATRICIA LODATO, MARCELO BAEZA, VÍCTOR CIFUENTES   +10 more
doaj  

Characteristics and practices of school-based cluster randomised controlled trials for improving health outcomes in pupils in the United Kingdom: a methodological systematic review

BMC Medical Research Methodology, 2021
Background Cluster randomised trials (CRTs) are increasingly used to evaluate non-pharmacological interventions for improving child health. Although methodological challenges of CRTs are well documented, the characteristics of school-based CRTs with ...
Kitty Parker, Michael Nunns, ZhiMin Xiao, Tamsin Ford, Obioha C. Ukoumunne   +4 more
doaj   +1 more source

CSS091109:035759+102943 - a candidate polar

, 2012
We report optical time-resolved photometry of the CRTS transient CSS091109:035759+102943. Pronounced orbital variability with a 114 min period, large X-ray variability and the IR to X-ray spectral energy distribution suggest a classification as a ...
Brinkworth, Drake, Hoard, Kirkpatrick, Knigge, Szkody, Watson   +6 more
core   +1 more source

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, EarlyView.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source

Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022

BMJ Open
Objective Cluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise complex ethical issues.
Shaun Treweek, Karla Hemming, Monica Taljaard, Lawrence Mbuagbaw, Charles Weijer, Cory E Goldstein, Fernando Althabe, Mira Johri, Vivian A Welch, Rieke van der Graaf, Rashida A Ferrand, Stuart G Nicholls, Yacine Marouf, Julia F Shaw, Anand Sergeant   +14 more
doaj   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio‐Immunotherapy

Advanced Science, EarlyView.
A CD44‐targeted MnPt bimetallic nanozyme (HD@MnO2) integrates multienzyme‐like activity with cGAS–STING activation to boost radio‐immunotherapy. Through cascade biocatalysis, it depletes glutathione, relieves hypoxia, and amplifies ROS, enhancing radiotherapy‐induced DNA damage and immunogenic cell death. The nanozyme promotes dendritic cell maturation
Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao   +8 more
wiley   +1 more source

Propensity score to detect baseline imbalance in cluster randomized trials: the role of the c-statistic

BMC Medical Research Methodology, 2016
Background Despite randomization, baseline imbalance and confounding bias may occur in cluster randomized trials (CRTs). Covariate imbalance may jeopardize the validity of statistical inferences if they occur on prognostic factors. Thus, the diagnosis of
Clémence Leyrat, Agnès Caille, Yohann Foucher, Bruno Giraudeau   +3 more
doaj   +1 more source

Accessibility and interventions of crisis resolution teams: a multicenter study of team practices and team differences in Norway

BMC Psychiatry, 2022
Background Components of crisis resolution teams’ (CRTs) practices have been defined in recommendations and a fidelity scale, and surveys have reported how team leaders describe CRT practices.
Torleif Ruud, Katrine Høyer Holgersen, Nina Hasselberg, Johan Siqveland   +3 more
doaj   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source