Results 71 to 80 of about 14,964 (269)

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

BELARUSIAN PROJECT “ASTROBLOKNOT” (ASTRONOMICAL NOTEBOOK) AND DATA MINING: RESULTS OBTAINED IN THE CONSTELLATION OF EQUULEUS

Odessa Astronomical Publications, 2013
Many photometric sky surveys are currently available on the  open-access web-sources. The Northern Sky Variability Survey (NSVS), the All Sky Automated Survey 3 (ASAS-3) and the Catalina Real-Time Transient Survey (CRTS) are the most popular among them ...
Ivan Sergey, Sergei Dubrouski, Igor Baluk, Alexander Pobiacha   +3 more
doaj   +1 more source

SN 2016iet: The Pulsational or Pair Instability Explosion of a Low Metallicity Massive CO Core Embedded in a Dense Hydrogen-Poor Circumstellar Medium

, 2019
We present optical photometry and spectroscopy of SN 2016iet, an unprecedented Type I supernova (SN) at $z=0.0676$ with no obvious analog in the existing literature.
Berger, Edo, Blanchard, Peter K., Chornock, Ryan, Cowperthwaite, Philip S., Gomez, Sebastian, Hosseinzadeh, Griffin, Leja, Joel, Nicholl, Matt, Patton, Locke, Villar, V. Ashley   +9 more
core   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Comparison of registered and published intervention fidelity assessment in cluster randomised trials of public health interventions in low- and middle-income countries: systematic review

Trials, 2018
Background Cluster randomised trials (CRTs) are a key instrument to evaluate public health interventions. Fidelity assessment examines study processes to gauge whether an intervention was delivered as initially planned.
Myriam Cielo Pérez, Nanor Minoyan, Valéry Ridde, Marie-Pierre Sylvestre, Mira Johri   +4 more
doaj   +1 more source

Charting Unexplored Dwarf Galaxy Territory With RR Lyrae

, 2015
Observational bias against finding Milky Way (MW) dwarf galaxies at low Galactic latitudes (b < 20 deg) and at low surface brightnesses (fainter than 29 mag arcsec^-2, in the V-band) currently limits our understanding of the faintest limits of the galaxy
Baker, Mariah, Willman, Beth
core   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Crisis resolution and home treatment: stakeholders’ views on critical ingredients and implementation in England

BMC Psychiatry, 2017
Background Crisis resolution teams (CRTs) can provide effective home-based treatment for acute mental health crises, although critical ingredients of the model have not been clearly identified, and implementation has been inconsistent. In order to inform
Nicola Morant, Brynmor Lloyd-Evans, Danielle Lamb, Kate Fullarton, Eleanor Brown, Beth Paterson, Hannah Istead, Kathleen Kelly, David Hindle, Sarah Fahmy, Claire Henderson, Oliver Mason, Sonia Johnson, CORE Service User and Carer Working groups   +13 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

CRTFASTGEEPWR: A SAS Macro for Power of Generalized Estimating Equations Analysis of Multi-Period Cluster Randomized Trials with Application to Stepped Wedge Designs

Journal of Statistical Software
Multi-period cluster randomized trials (CRTs) are increasingly used for the evaluation of interventions delivered at the group level. While generalized estimating equations (GEE) are commonly used to provide population-averaged inference in CRTs, there ...
Ying Zhang, John S. Preisser, Fan Li, Elizabeth L. Turner, Paul J. Rathouz   +4 more
doaj   +1 more source