Results 41 to 50 of about 6,641 (299)

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Experimental Investigation on Vibro-Acoustic Characteristics of Stiffened Plate Structures with Different Welding Parameters

Journal of Marine Science and Engineering, 2022
Varied welding process parameters result in different welding energy inputs and welding residual stresses, significantly impacting the vibro-acoustic characteristics.
Ziheng Chen, Xiaodan Jia, Yongshui Lin, Huabing Liu, Weiguo Wu   +4 more
doaj   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Resource allocation and growth strategies in a multi‐plant firm: Kanegafuchi Spinners in the early 20th century

Strategic Management Journal, EarlyView., 2023
Abstract Research Summary Using detailed plant‐ and individual‐level data from a major Japanese cotton spinning company in the early 20th century, we examine the within‐firm allocation of skilled human capital in conjunction with investment in physical capital, accompanying the firm's evolving strategic priorities.
Shotaro Yamaguchi, Serguey Braguinsky, Tetsuji Okazaki, Takenobu Yuki   +3 more
wiley   +1 more source

The cruise shipping industry in the corporate mergers and overpanamax eras. A comparison with the container shipping industry

Belgeo, 2004
After container shipping, the cruise shipping industry has entered recently into the overpanamax era, in a typical quest for economies of scale, at the same time as it was searching for economies of scope, including through corporate mergers.
Jacques Charlier
doaj   +1 more source

The emergence of cruise tourism in Iran [PDF]

Journal of Tourism Futures, 2018
Purpose - Iran is a country with substantial tourism potential. Iran’s tourism industry, however, was side-lined for decades due to international sanctions.
Masood Khodadadi
doaj   +1 more source

Scanning Parametric Sediment Echosounder as Tool for Underwater Archaeological Prospection

Archaeological Prospection, EarlyView.
ABSTRACT Underwater cultural heritage 3D prospection techniques, especially for remains that are partly buried in the ground, are only very rarely available and often can only be applied with considerable technical effort. To overcome this limitation, we evaluate a methodological adaption of widely used and available single channel parametric sediment ...
Dennis Wilken, Philipp Held, Jacob Geersen, Marcel Bradtmöller, Peter Feldens, Jens Schneider v. Deimling   +5 more
wiley   +1 more source

A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome

Arthritis &Rheumatology, EarlyView.
Objective Still disease represents a prototypical polygenic systemic autoinflammatory disease, characterized by recurrent systemic inflammation and dysregulation of innate immunity. Despite extensive clinical characterization, familial clustering Still disease remains unreported.
Longfang Chen, Qihua Dai, Yu Xiao, Jialin Dai, Mengyan Wang, Yuning Ma, Yujie Shen, Zhimo Xu, Jianfen Meng, Xia Chen, Da Yi, Yue Sun, Hui Shi, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Huihui Chi, Zhuochao Zhou, Tingting Liu, Jialin Teng, Chengde Yang, Jinchao Jia, Qiongyi Hu   +23 more
wiley   +1 more source

COVID-19 and the global cruise ship industry: potential recovery and reformation pathways

Bulletin of Geography. Socio-Economic Series, 2022
The cruise ship industry was one of the fastest growing subsectors of the tourism industry before the advent of COVID-19. This paper examines the prospects and recovery of the cruise ship industry from the devastating impacts of COVID-19 on the industry.
David Chikodzi, Godwell Nhamo, Kaitano Dube   +2 more
doaj   +1 more source

Sailing From Penalties to Accountability: Business Strategies and Governance for Firms to Innovate After Environmental Misconduct

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms' continuous pursuit of making a profit in the competitive market may ignore the actions related to environmental responsibilities. This set of actions for financial gains constitutes environmental misconduct, which not only harms ecosystems and communities but also brings reputational damage. Negative press and social media amplification
Ashutosh Singh, Salwa Saleh Almasabi, Ajay Kumar Patel, Priyanka Malik   +3 more
wiley   +1 more source