Results 61 to 70 of about 913,860 (294)

Use of Hyperbaric Oxygen Therapy for Preventing Amputation in Severe Crush Injury due to Earthquake in a Pediatric Patient: A Case Report [PDF]

Hyperbaric oxygen therapy (HBOT) is a treatment modality whose indications expand over time. Although its use is not as widespread in children as in adults, HBOT can also be applied in pediatric patients with similar indications.
Ayhan Işık Erdal, Nazmi Mutlu Karakaş, Ebru Azapağası, Muhittin Döndü   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Type grouping in rat skeletal muscle after crush injury

, 2011
Object Accuracy of reinnervation is an important factor that determines outcome after nerve injury and repair. Type grouping—the clustering of muscle fibers of the same type after reinnervation—can be used to investigate the accuracy of reinnervation ...
M. Sarah S. Bovenberg, Feirabend, H.K.P., Carmen L. A. M. Vleggeert-Lankamp, Egbert A. J. F. Lakke, Ruiter, G.C.W. de, Bovenberg, M.S.S., Hans K. P. Feirabend, Degeling, M.H., Lakke, E.A.J.F., Godard C. W. de Ruiter, M. Hannah Degeling, Vleggeert-Lankamp, C.L.A.M.   +11 more
core   +1 more source

Effect of core crush on honeycomb sandwich panels

, 2010
Nomex honeycomb is used as the predominate core material in aerospace standard sandwich structure. To provide aerospace standard composite face sheets it is necessary to cure the sandwich structure in an autoclave at elevated pressure.
Crump, D.A., Griffith, D., Dulieu-Barton, J.M.   +2 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Crush injuries and crush syndrome -a review. Part 2: the local injury [PDF]

, 2010
Crush injuries can occur in considerable numbers following natural disasters or acts of war and terrorism. They can also occur sporadically after industrial accidents or following periods of unconsciousness from drug intoxication, anaesthesia, trauma or ...
Charitha Weerasinghe, Keith Porter, Nikolas A Jagodzinski   +2 more
core   +2 more sources

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

After an earthquake : management of crush injuries & crush syndrome [PDF]

"Crush injury and crush syndrome may result from structural collapse during an earthquake. Crush injury is defined as compression of extremities or other parts of the body that causes muscle swelling and/or neurological disturbances in the affected areas

core