Results 251 to 260 of about 3,406,124 (331)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Lesionectomy as management for super-refractory status epilepticus due to focal cortical dysplasia: illustrative case. [PDF]

J Neurosurg Case Lessons
Gonzalez-Salido J, Fuentes-Calvo I, Martinez-Medina S, Colado-Martinez J, Marin-Castañeda LA, Robles-Lomelin P, Cienfuegos-Meza J, Díaz-Martínez R, Ramos-Sanchez RJ, Vasquez-Lopez F, Vázquez-Cruz BC, Vera López JC, Salgado-Deza M, Alcala-Romero C, Vázquez-Hernández OI, Santizo-Nanduca I, Moreno Avellán Á, Ferndandez-Gonzalez-Aragon M, Arellano-Reynoso A, Sebastián-Díaz MA, Cruz-Pérez J, Tena Suck ML, Martínez-Juárez IE.   +22 more
europepmc   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Draft whole-genome sequences of ancestral and modern <i>Mycobacterium tuberculosis</i> Beijing strains with different patterns of virulence. [PDF]

Microbiol Resour Announc
Gomes L, Machado E, Abanto Marin M, Vasconcellos S, de Miranda AB, Mokrousov I, Lasunskaia E, Suffys P.   +7 more
europepmc   +1 more source

Genetic Determinants Linked to MDR/XDR in Pseudomonas aeruginosa Strains from a Mexican Tertiary Hospital. [PDF]

Pathogens
Nicolas-Sayago L, Loyola-Cruz MÁ, Vásquez-Martínez Y, Cortez-San Martín M, Márquez-Valdelamar LM, Cruz-Cruz C, Durán-Manuel EM, Ruíz-Valdés M, Calzada-Mendoza CC, Rojas-Bernabé A, Tamayo-Ordóñez MC, Tamayo-Ordóñez YJ, Castañeda-Ortega JC, López-Martínez B, Hernández-Castellanos B, Moreno-Torres D, Castro-Escarpulli G, Bello-López JM.   +17 more
europepmc   +1 more source

Influence of Wood Chemical Composition on Liquefaction Efficiency and Polyurethane Foam Properties: A Study of Red Angico and Mahogany. [PDF]

Materials (Basel)
Silva E, Cruz-Lopes L, Domingos I, Gonçalves F, Cruz BDS, Fassarella M, Almeida AT, Esteves B.   +7 more
europepmc   +1 more source