Results 31 to 40 of about 657,223 (265)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
El comportamiento de las mujeres discípulas en la pasión de Marcos
Estudios Eclesiásticos, 2016 El seguimiento de Jesús constituye uno de los temas mayores del Evangelio de Marcos. Aunque todo el escrito gira en torno a la vida y obra de Jesús, también los discípulos juegan un papel destacado, siempre acompañando a Cristo.
Luis Ángel Montes Peral
doaj
Novos táxons de Apomecynini (Coleoptera, Cerambycidae, Lamiinae)
Papéis Avulsos de Zoologia, 2006 Novos táxons de Apomecynini (Coleoptera, Cerambycidae, Lamiinae). Novos táxons descritos: Adetus curupira sp. nov. do Brasil, Pará; Potiatuca gen. nov., espécie-tipo, P. ingridae sp. nov. do Brasil, Rio Grande do Sul; Parmenonta lenticula sp. nov.
Maria Helena M. Galileo +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Historia y Sociedad, 2015 Los barones del Oriente. El poder en Santa Cruz ayer y hoy (Santa Cruz de la Sierra: Fundación TIERRA, 2008)
Carla Estefanía Cirelli
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
La crux gemmata de la basílica de San Filóxeno de Oxirrinco (El-Bahnasa, Egipto)
ImafronteEl artículo se centra en el estudio de una crux gemmata descubierta en la basílica de San Filóxeno en Oxirrinco (Egipto), explorando su contexto histórico, significado simbólico e iconografía.
José Javier Martínez García +1 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source