Results 61 to 70 of about 2,936 (203)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Real‐World Effectiveness of Mepolizumab in Patients With Chronic Rhinosinusitis With Nasal Polyps: Findings From the European CRS Outcome Registry (CHRINOSOR)

Clinical and Translational Allergy, Volume 16, Issue 2, February 2026.
ABSTRACT Background The SYNAPSE phase 3 study demonstrated that mepolizumab significantly improves nasal polyp score (NPS), quality of life and symptom severity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Objective We aimed to evaluate mepolizumab effectiveness in a real‐world cohort from 12 tertiary centers in 6 European ...
Isam Alobid, Sven F. Seys, Joost de Kinderen, Valérie Hox, Carlo Cavaliere, Alexandros Andrianakis, Sven Schneider, Martin Wagenmann, Martin Bruch, Adriana Izquierdo‐Domínguez, Xavier Gonzalez‐Compta, Laura Pardo Muñoz, Laura Van Gerven, Peter W. Hellings, Geoffrey Mortuaire, Martin Burian, Mireia Golet‐Fors, Mathilde Moyaert, Peter‐Valentin Tomazic, Giulia Bettio, Marco de Vincentiis, Zuzana Diamant, Julia Eckl‐Dorna, Gert Mariën, Simonetta Masieri, Christina Morgenstern, Kathrin Scheckenbach, Aldine Tu, Camilo Rodriguez van Strahlen, Claus Bachert, CHRINOSOR consortium   +30 more
wiley   +1 more source

Using household death questions from surveys to assess adult mortality in periods of health crisis: An application for Peru, 2018–2022 [PDF]

Demographic Research
BACKGROUND: The COVID-19 pandemic highlighted the importance of civil registration and vital statistics (CRVS) systems for tracking and monitoring mortality outcomes during a public health crisis, especially in low- and middle-income countries ...
José Henrique Costa Monteiro da Silva, Helena Cruz Castanheira   +1 more
doaj   +1 more source

Precisely tracking childhood death [PDF]

, 2017
Little is known about the specific causes of neonatal and under-five childhood death in high-mortality geographic regions due to a lack of primary data and dependence on inaccurate tools, such as verbal ...
Bassat Orellana, Quique, Breiman, Robert F., Dowell, Scott F., Farag, Tamer H., Heaton, Penny M., Koplan, Jeffrey P., Madhi, Shabir A., Menéndez, Clara, Mundel, Trevor, Ordi i Majà, Jaume   +9 more
core   +1 more source

Advances in the Development of Lipid Nanoparticles for mRNA Delivery

Small Structures, Volume 7, Issue 2, February 2026.
This review provides an integrated overview of mRNA–lipid nanoparticle (LNP) design, including lipid composition, scalable manufacturing, and structure–activity relationships. We highlight strategies for targeted delivery, physicochemical tuning, and high‐throughput screening such as DNA barcoding.
Xing Wang, Letao Xu, Zhenwei Lan, Yue Hui, Yun Liu, Guangze Yang, Chun‐Xia Zhao   +6 more
wiley   +1 more source

Impact of Institutionalisation of Births on Health Policies and Birth Registration in India

Annals of Global Health
Background: The Registration of Births and Deaths Act (RBD) of 1969 in India mandates continuous recording of vital events; however, after more than 50 years of its enactment, universality remains elusive.
Sheetal Verma, Laxmi Kant Dwivedi, Ritul Kamal   +2 more
doaj   +1 more source

A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Passive epicardial sleeves are evaluated in 3D in‐silico heart models to reveal how sleeve geometry, stiffness, anisotropy, and metamaterial architecture influence cardiac mechanics after myocardial infarction. A continuum‐to‐auxetic design exploration shows that region‐specific mechanical engagement can reduce infarct bulging and modulate torsional ...
Vahid Naeini, Emilio A. Mendiola, Ahmad Rafsanjani, Fergal B. Coulter, Qian Xiang, Jianyi Zhang, Peter Vanderslice, Vahid Serpooshan, Reza Avazmohammadi   +8 more
wiley   +1 more source

Support Structure Modelling in Actuator Line Method Large Eddy Simulations of Wind Turbine Wakes

Wind Energy, Volume 29, Issue 1, January 2026.
ABSTRACT While advancements in the prediction of wind turbine loads and wakes within the actuator line method large eddy simulation (ALM‐LES) framework have been an active research topic in recent years, the modelling of the tower and nacelle has received comparatively less attention.
Markella Zormpa, Christopher R. Vogel, Richard H. J. Willden   +2 more
wiley   +1 more source

Regional Energy Transition Amidst Trade and Bloc Rivalries: Proactive or Counterproductive Democratic Governance?

International Journal of Energy Research, Volume 2026, Issue 1, 2026.
Trade fragmentation (TDF) and bloc rivalries impact energy transition pathways through raw material trade and the decisions of major blocks. Democratic governance, whether centralized or populist, also influences trade, bloc decisions, and the energy transition.
Md. Monirul Islam, Oleg Mariev, Faroque Ahmed, Paolo Castaldo   +3 more
wiley   +1 more source

Where there is no hospital: improving the notification of community deaths

BMC Medicine, 2020
Background Globally, an estimated two-thirds of all deaths occur in the community, the majority of which are not attended by a physician and remain unregistered.
Tim Adair, Megha Rajasekhar, Khin Sandar Bo, John Hart, Viola Kwa, Md. Ashfaqul Amin Mukut, Matthew Reeve, Nicola Richards, Margarita Ronderos-Torres, Don de Savigny, Daniel Cobos Muñoz, Alan D. Lopez   +11 more
doaj   +1 more source