Results 221 to 230 of about 248,941 (304)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Sandwich-Architected Hybrid Organic Crystals with Humidity-Temperature Sensing and Cryogenic Photothermal Actuation. [PDF]

Nanomicro Lett
Lan L, Wang L, Wang C, Zhang H.
europepmc   +1 more source

Multi‐Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean‐Type and Chinese Indigenous Pigs

Advanced Science, EarlyView.
Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng, Hainan Wu, Min Liu, Kunpeng Wu, Shuntao Huang, Zulfiqar Ahmed, Lenox Pius, Mengjin Zhu, Dequan Xu   +8 more
wiley   +1 more source

Corrections to "Dynamic Self-Assembly and Stimuli-Responsive Disassembly of Bioactive-Loaded Cubosomes in Biomimetic Media Traced by Real-Time Small-Angle X-ray Scattering and Cryogenic Transmission Electron Microscopy". [PDF]

ACS Appl Mater Interfaces
Madrid RRM, Angelova A, Angelov B, Manna G, Mathews PD, Mertins O.   +5 more
europepmc   +1 more source

Molecularly Engineered Phenoxazinone‐Skeleton Cascade‐Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis‐Mediated Parkinson's Disease

Advanced Science, EarlyView.
A series of Fe2+/viscosity cascade‐activated NIR fluorescence probes (NP1–5) are synthesized, and NP3 is selected for its optimal properties. To verify application of NP3 in ferroptosis intervention in PD, PQR NPs, is constructed by NP3 and quercetin self‐assembling.
Lixia Guo, Tao Liu, Hongfei Wang, Qi Gao, Zhaobo Yang, Zumeng Wang, Chenlong Li, Yubing Kang, Kahleong Lim, Wen Liu, Li Lu, Chengwu Zhang   +11 more
wiley   +1 more source

Quasistatic and dynamic mechanical response of laser powder bed fusion manufactured AA2219 alloy at cryogenic temperature. [PDF]

Sci Rep
Tumulu SK, Hudon P, Brochu M.
europepmc   +1 more source

Current‐Driven Nonreciprocal Response of Nonequilibrium Skyrmions

Advanced Science, EarlyView.
A skyrmion holds great promise for spintronic applications owing to its intrinsic topological stability and high mobility under ultra‐low current excitation. Here, by means of in situ electron microscopy, we demonstrate a skyrmion diode effect and the associated current‐driven nonreciprocal skyrmion dynamics in a designed FeGe‐based microdevice.
Xiuzhen Yu, Soju Furuta, Xichao Zhang, Yi‐Ling Chiew, Kiyomi Nakajima, Kosuke Karube, Naoya Kanazawa, Yasujiro Taguchi, Yoshinori Tokura, Masahito Mochizuki, Fumitaka Kagawa   +10 more
wiley   +1 more source

Particle background characterization and prediction for the NUCLEUS reactor CE ν NS experiment. [PDF]

Eur Phys J C Part Fields
Abele H, Angloher G, Arnold B, Corona MA, Bento A, Bossio E, Buchsteiner F, Burkhart J, Cappella F, Cappelli M, Casali N, Cerulli R, Cruciani A, Del Castello G, Del Gallo Roccagiovine M, Dorer S, Erhart A, Friedl M, Fichtinger S, Ghete VM, Giammei M, Goupy C, Hauff D, Jeanneau F, Jericha E, Kaznacheeva M, Kluck H, Langenkämper A, Lasserre T, Lhuillier D, Mancuso M, Martin R, Mauri B, Mazzolari A, McCallin L, Neyrial H, Nones C, Oberauer L, Ortmann T, Peters L, Petricca F, Potzel W, Pröbst F, Pucci F, Reindl F, Romagnoni M, Rothe J, Schermer N, Schieck J, Schönert S, Schwertner C, Scola L, Soum-Sidikov G, Stodolsky L, Strauss R, Thalmeier R, Tomei C, Vignati M, Vivier M, Wex A.   +59 more
europepmc   +1 more source

Modulating Persistent Photoconductivity through Barrier Engineering for High‐performance and Multifunctional Two‐dimensional Optoelectronic Devices

Advanced Science, EarlyView.
Schottky barrier engineering using van der Waals contacts enables effective modulation of persistent photoconductivity (PPC) in optoelectronic devices. A high persistent photoconductivity gain (PPCG) (307.6%) is achieved in a high‐barrier Au/MoS2 junction, supporting photomemory and optoelectronic synaptic behaviors. A low PPCG (4.72%) is achieved in a
Panpan Huo, Xinhao Zhang, Xiangyong Cui, Yeming Wang, Dong Zhou, Baoyuan Man, Il Jeon, Won Jong Yoo, Cheng Yang   +8 more
wiley   +1 more source

Hybrid cryo-nano MQL strategy for sustainable and high-performance machining of Monel 400. [PDF]

Sci Rep
Rao GN, Sivalingam S, Patel D, Arunkumar DT, Sankar SL, Pattanayak B, Juneja S, Aggarwal S, Bhowmik A, Abate L.   +9 more
europepmc   +1 more source