Results 21 to 30 of about 13,630 (218)

Voriconazole as a secondary prophylaxis for cryptococcal meningitis during hematopoietic stem cell transplantation

IDCases, 2021
Antifungal prophylaxis is crucial for successful hematopoietic stem cell transplantation (HSCT). Maintenance therapy with fluconazole (FLCZ) is generally prescribed as secondary prophylaxis in patients with human immunodeficiency virus infection and non ...
Emiko Kashima, Keiki Nagaharu, Kazuko Ino, Yuka Sugimoto, Atsushi Fujieda, Keiki Kawakami, Isao Tawara   +6 more
doaj   +1 more source

“False negative” CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature

Medical Mycology Case Reports, 2020
There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to ...
Morris K. Rutakingirwa, Tadeo K. Kiiza, Joshua Rhein   +2 more
doaj   +1 more source

Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa [PDF]

, 2015
This work was supported by Wellcome Trust (UK) (www.wellcome.ac.uk) awards to TB (WT069991), GM (WT098316), and JNJ (WT081794); Medical Research Council (MRC UK) (www.mrc.ac.uk) awards to MCF (K000373/1), RCM (G0601171), TSH (G1002327); European Research
Fisher, Matthew C, Matthew C Fisher, Matthew C. Fisher (129755), Angela Loyse (292490), Meintjes, Graeme, Fisher, Matthew C., Emma J. Robertson (760738), Sabiiti, Wilber, O'Hanlon, SJ, O'Hanlon, Simon J, Joseph N Jarvis, Tihana Bicanic (718812), Thomas S. Harrison (222993), Fisher, MC, Karen M Fuentes-Cabrejo, Fuentes-Cabrejo, KM, Fuentes-Cabrejo, Karen M, Angela Loyse, Fisher, M, Harrison, Thomas S, Harrison, TS, Robertson, EJ, Simon J. O’Hanlon (760740), Loyse, Angela, Meintjes, G, Simon J O'Hanlon, Robin C May, Jarvis, Joseph N, Emma J Robertson, Wilber Sabiiti (170648), Thomas S Harrison, Mathew A. Beale (663616), Wilber Sabiiti, Robertson, Emma J, Joseph N. Jarvis (435279), Robertson, Emma J., Jarvis, JN, May, Robin C, Mathew A Beale, Karen M. Fuentes-Cabrejo (760739), Graeme Meintjes (221054), Beale, Mathew A, Tihana Bicanic, Sabiiti, W, Bicanic, T, May, RC, Loyse, A, May, Robin C; id_orcid, Bicanic, Tihana, Graeme Meintjes, Beale, MA, Robin C. May (170650)   +51 more
core   +1 more source

Cryptococcal antigenemia is associated with meningitis or death in HIV-infected adults with CD4 100–200 cells/mm3

BMC Infectious Diseases, 2020
Background Cryptococcal antigen (CrAg) screening with fluconazole prophylaxis has been shown to prevent cryptococcal meningitis and mortality for people living with HIV (PLWH) with CD4 
James Wykowski, Sean R. Galagan, Sabina Govere, Carole L. Wallis, Mahomed-Yunus Moosa, Connie Celum, Paul K. Drain   +6 more
doaj   +1 more source

A case report of a brain herniation secondary to cryptococcal meningitis with elevated intracranial pressure in a patient with Human Immunodeficiency Virus/Acquired immunodeficiency syndrome (HIV/AIDS)

IDCases, 2022
Background: Cryptococcal meningitis is a major opportunistic infection in individuals with HIV. The worldwide annual incidence is estimated to be approximately one million cases per year, with the most significant burden in sub-Saharan Africa.
Nehemias Guevara, Abdulrasheed Akande, Mailing Flores Chang, Jane Atallah, Carol Epstein   +4 more
doaj   +1 more source

AMBITION-cm : intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa : study protocol for a randomized controlled trial [PDF]

, 2015
Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine, and difficulties administering 14 days of amphotericin B are key ...
Leeme, Tshepo, Síle F. Molloy, Changalucha, John M., Molefi, Mooketsi, Molloy, Síle F, Meintjes, Graeme, Molloy, Síle F., Goldberg, Drew W, John R. Perfect, Drew W. Goldberg, Kalluvya, Samuel, Cainelli, Francesca, Letang, Emili, Ndhlovu, Chiratidzo E, Perfect, John R, Ndhlovu, Chiratidzo E., Bisson, Gregory P., Miriam Haverkamp, Burton, Rosie, Rosie Burton, Tariro Makadzange, Harrison, Thomas S, Francesca Cainelli, Hope, William, Haverkamp, Miriam, Chiratidzo E. Ndhlovu, Harrison, Thomas S., Jarvis, Joseph N., Chofle, Awilly A, William Hope, Jarvis, Joseph N, Changalucha, John M, Fenner, Lukas, Perfect, John R., Makadzange, Tariro, Joseph N. Jarvis, Tshepo Leeme, Mooketsi Molefi, Nametso Lekwape, Lekwape, Nametso, John M. Changalucha, Emili Letang, Goldberg, Drew W., Lukas Fenner, Bisson, Gregory P, Awilly A. Chofle, Samuel Kalluvya, Thomas S. Harrison, Graeme Meintjes, Chofle, Awilly A., Gregory P. Bisson   +50 more
core   +1 more source

Low CD4 count plus coma predicts cryptococcal meningitis in Tanzania

BMC Infectious Diseases, 2007
Background Largely due to the lack of diagnostic reagents, the prevalence and clinical presentation of cryptococcal meningitis in Tanzania is poorly understood. This in turn is limiting the impact of increased fluconazole availability.
Mueller Andreas, Swai Ndealilia S, Mchele John PD, Maro Venance P, Hawkins Alexander T, Kisenge Peter R, Houpt Eric R   +6 more
doaj   +1 more source

Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. [PDF]

, 2010
BACKGROUND: The presentation and causes of adult meningitis in South Africa have changed substantially as a result of HIV. Knowledge of aetiology and laboratory findings in patients presenting with meningitis are important in guiding management.
Crede Tom, Williams, A, Thomas S Harrison, Meintjes, Graeme, Brown Yolande, Harrison Thomas S, Jarvis, Joseph, Yolande Brown, Tom Crede, Joseph N Jarvis, Jarvis, JN, Meintjes Graeme, Harrison, Thomas, Crede, Tom, Anthony Williams, Jarvis Joseph N, Harrison, Thomas S, Brown, Y, Brown, Yolande, Harrison, TS, Crede, T, Williams, Anthony, Graeme Meintjes, Williams Anthony, Meintjes, G, Jarvis, Joseph N   +25 more
core   +1 more source

Association of Fcγ receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients. [PDF]

PLoS ONE, 2012
BACKGROUND: As important regulators of the immune system, the human Fcγ receptors (FcγRs) have been demonstrated to play important roles in the pathogenesis of various infectious diseases.
Xiu-Ping Hu, Ji-Qin Wu, Li-Ping Zhu, Xuan Wang, Bin Xu, Rui-Ying Wang, Xue-Ting Ou, Xin-Hua Weng   +7 more
doaj   +1 more source

Another case of cryptococcal meningitis in a person without HIV who injects drugs: A possible risk factor in need of further investigation

Medical Mycology Case Reports, 2022
Cryptococcal meningitis is a fungal central nervous infection typically occurring in patients with severe immunocompromise. We present a case of cryptococcal meningitis occurring in a patient with active injection drug use (IDU) but no immunocompromising
L. Madeline McCrary, Ryan Paulus, J. Kyle Melvin, John Perfect, Becky L. White   +4 more
doaj   +1 more source