Neurobasal medium enhances titan cell formation in Cryptococcus spp. [PDF]
Mem Inst Oswaldo CruzBACKGROUND Titan cells in Cryptococcus species play a critical role in fungal virulence by resisting oxidative stress, phagocytosis, and antifungal treatments. Developing reliable methods to induce titan cells is crucial for understanding the mechanisms of Cryptococcus pathogenesis.
Godoy J +4 more
europepmc +3 more sources
Modification of Hinge/Transmembrane and Signal Transduction Domains Improves the Expression and Signaling Threshold of GXMR-CAR Specific to Cryptococcus spp. [PDF]
Cells, 2022 Chimeric antigen receptors (CARs) redirect T cells to recognize a specific target. CAR components play a pivotal role in antigen specificity, structure stability, expression on cell surface, and induction of cellular activation, which together determine ...
Dos Santos MH +3 more
europepmc +4 more sources
Thiazole derivatives act on virulence factors ofCryptococcusspp. [PDF]
Medical Mycology, 2017 Cryptococcosis is an opportunistic or primary fungal infection considered to be the most prevalent fatal fungal disease worldwide. Owing to the limited number of available drugs, it is necessary to search for novel antifungal compounds. In the present work, we assessed the antifungal efficacy of three thiazole derivatives (1, 2, and 3). We conducted in
Nívea Pereira de Sá +7 more
semanticscholar +5 more sources
FATORES DE VIRULÊNCIA E SUSCEPTIBILIDADE A ANTIFÚNGICOS DE Cryptococcus spp.
Arquivos de Ciências da Saúde da UNIPAR, 2020 Criptococose é uma doença grave que afeta tanto imunocomprometidos quanto imunocompetentes, com isso analisar a virulência é fundamental para novas terapêuticas. Objetivo: analisar a capacidade de virulência e susceptibilidade aos antifúngicos de Cryptococcus spp. isolados de líquor de pacientes de hospital do norte do Paraná. Métodos: a partir de dois
Flávia Franco Veiga +3 more
semanticscholar +5 more sources
Non-self glycan structures as possible modulators of cancer progression: would polysaccharides from Cryptococcus spp. impact this phenomenon? [PDF]
Braz J Microbiol, 2023 Diniz-Lima I +8 more
europepmc +4 more sources
A Highly Active Triterpene Derivative Capable |of Biofilm Damage to Control Cryptococcus spp. [PDF]
Biomolecules, 2019 Cryptococcus neoformans is an encapsulated yeast responsible for more than 180,000 deaths per year. The standard therapeutic approach against cryptococcosis is a combination of amphotericin B with flucytosine. In countries where cryptococcosis is most prevalent, 5-fluorocytosine is rarely available, and amphotericin B requires intravenous ...
Krummenauer ME +6 more
europepmc +5 more sources
Quercetin and rutin as potential agents antifungal against Cryptococcus spp [PDF]
Brazilian Journal of Biology, 2016 Abstract Amphotericin B is a fungicidal substance that is treatment of choice for most systemic fungal infections affecting as cryptococcosis the immunocompromised patients. However, severe side effects have limited the utility of this drug. The aim of this study was to evaluate the antifungal effect of the combination of amphotericin B with quercetin ...
Oliveira, V. M. +3 more
openaire +6 more sources
Species distribution, antifungal susceptibility, and clinical profiles of patients with osteoarticular fungal Infections: A retrospective study [PDF]
New Microbes and New InfectionsBackground: Osteoarticular fungal infections (OAFIs), including fungal osteomyelitis and septic arthritis, represent uncommon but clinically significant complications in musculoskeletal care. Current management remains challenging due to limited evidence
Jie Liu +4 more
doaj +2 more sources
Ear damage caused by Cryptococcus spp. in guinea pigs: case report
Research, Society and Development, 2022 Cryptococcus spp affects mainly dogs and cats, however, there are reports in other animal species, such as guinea pigs. The objective of this study is to report a case of a lesion by cryptococcosis in a guinea pig's auricles. The animal had firm nodules under the touch in both auricles, being one of them with a granulomatous aspect, both ulcerated ...
Tainá Luana Vieira Lopes Zuchi +1 more
openaire +3 more sources
Search for Cryptococcus neoformans/gattii Complexes and Related Genera (Filobasidium, Holtermanniella, Naganishia, Papiliotrema, Solicoccozyma, Vishniacozyma) spp. Biotope: Two Years Surveillance of Wild Avian Fauna in Southern France [PDF]
Journal of Fungi, 2022 Fungi belonging to the Cryptococcus genus and related genera (Filobasidium, Holtermanniella, Naganishia, Papiliotrema, Solicoccozyma, Vishniacozyma) are encapsulated yeasts found in either the environment or animal sources.
Sébastien Bertout +9 more
doaj +2 more sources