Results 31 to 40 of about 25,988 (233)

Mind the gap: Can we explain declining male reproductive health with known antiandrogens? [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Several countries have experienced rises in cryptorchidisms, hypospadias and testicular germ cell cancer. The reasons for these trends are largely unknown, but Skakkebaek
Andreas Kortenkamp, Berkowitz, Birkh  j, Carbone, Carmichael, Chia, Christiansen, Christiansen, Conacher, Covaci, Darbre, Ermler, Ermler, Fromme, Galassi, Hardell, Hardell, Hardell, Janjua, Jensen, Karrman, Karrman, Kjaerstad, Kojima, Kristensen, L  pez-Cervantes, Martin Scholze, Midasch, Neal, Nelson, Orton, Orton, Park, Pierik, Pierik, Rappaport, Schiavone, Schlumpf, Scholze, Sch  nfelder, Sibylle Ermler, Stoker, Suzuki, Swan, Swan, Vandenberg, Vinggaard, Wilson, Wine, You   +49 more
core   +1 more source

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]

, 2016
We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...
Bellingham, M., Cotinot, C., Evans, N.P., Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Rhind, S., Sharpe, R.M.   +7 more
core   +2 more sources

Flutamide-induced hypospadias in rats: A critical assessment. [PDF]

, 2017
This paper provides the first detailed description of flutamide-induced hypospadias in the rat based upon wholemount, histologic, three-dimensional reconstruction, scanning electron microscopic, and immunocytochemical analysis.
Baskin, Laurence, Cao, Mei, Cunha, Gerald R, Pask, Andrew, Sinclair, Adriane Watkins   +4 more
core   +2 more sources

Pivotal role of the muscle-contraction pathway in cryptorchidism and evidence for genomic connections with cardiomyopathy pathways in RASopathies [PDF]

, 2013
BACKGROUND: Cryptorchidism is the most frequent congenital disorder in male children; however the genetic causes of cryptorchidism remain poorly investigated.
Carlo V Cannistraci, Jernej Ogorevc, Minja Zorc, Peter Dovc, Tanja Kunej, Timothy Ravasi   +5 more
core   +1 more source

Testosterone and androstenedione concentrations in human testis and epididymis during the first two years of life [PDF]

, 1983
Testosterone and androstenedione were measured in testicular and epididymal tissue of 37 previously healthy infants between 1 and 24 months of age who died suddenly. In half of the patients elevated plasma levels of cortisol and androstenedione suggested
Bidlingmaier, F., Dörr, H. G., Eisenmenger, Wolfgang, Knorr, D., Kuhnle, U.   +4 more
core   +1 more source

Prevalence of SRY and DAX-1 gene deletion in patients with Cryptorchidism and Hypospadias – A Pilot study in North Indian Children

Asian Journal of Medical Sciences, 2015
Background: Cryptorchidism and hypospadias are common problems in males attending the pediatric surgery clinic. These two abnormalities are also associated with genetic syndromes/disorders of sexual development (DSD).
Krishna Mohan Gulla
doaj   +1 more source

Complex Genetic Architecture in RASopathies: Constitutional PTPN11 and Mosaic RIT1 Pathogenic Variants Underlying Severe Noonan Syndrome With Adult‐Onset Acute Myeloid Leukemia

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Noonan syndrome (NS) is a genetically heterogeneous disorder characterized by a broad spectrum of clinical features resulting from dysregulation of the RAS/MAPK pathway. Although complex genotypes are increasingly recognized in NS, cases harboring two distinct pathogenic variants in different NS genes remain extremely rare.
Francesco Prevedello, Dario Seif Ali, Chiara Piccolo, Chiara Rigon, Monica Forzan, Elena Tacchetto, Roberta Palmitessa, Davide Calosci, Leonardo Salviati, Carmela Gurrieri, Eva Trevisson   +10 more
wiley   +1 more source

Cryptorchidism and puberty

Frontiers in Endocrinology
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns.
Wiwat Rodprasert, Helena E. Virtanen, Jorma Toppari, Jorma Toppari, Jorma Toppari, Jorma Toppari   +5 more
doaj   +1 more source

Phenotype Expansion of Malan Syndrome: New Cases and a Review of the Literature

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Malan syndrome is an ultra‐rare overgrowth syndrome caused by pathogenic variants or deletions in nuclear factor one X (NFIX) located at 19p13.2. Here, we report a comprehensive literature review and phenotyping of known patients with Malan syndrome and present a novel cohort of eight patients.
Alex F. Nisbet, Sylvie A. Adams, Zoe S. Katz, Christal G. Delagrammatikas, Kosuke Izumi, Winifred Sigal, Kim Ventarola, Elaine H. Zackai, Julia E. Reid, Grant T. Liu, Jennifer M. Kalish   +10 more
wiley   +1 more source

Perfluorooctane sulfonate concentrations in amniotic fluid, biomarkers of fetal Leydig cell function, and cryptorchidism and hypospadias in Danish boys (1980–1996) [PDF]

, 2016
Background: Exposure to perfluorooctane sulfonate (PFOS) may potentially disturb fetal Leydig cell hormone production and male genital development. Objectives: We aimed to study the associations between levels of amniotic fluid PFOS, fetal steroid ...
Anand-Ivell R, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A.G. Jönsson, Christian H. Lindh, David M. Hougaard, European Commission., Gunnar Toft, Jauniaux E, Jens Peter Bonde, Knudsen LB, Morten S. Lindhard, Pedersen CB, Ravinder Anand-Ivell, Richard Ivell   +14 more
core   +2 more sources