Results 51 to 60 of about 1,125,262 (294)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Advances in Crystal Growth: Pioneering Materials for Tomorrow’s Technologies

Crystals
Crystal growth is inherently multidisciplinary, encompassing fields such as thermodynamics and kinetics, fluid dynamics, solution and solid-state chemistry, process engineering, and defects engineering to name a few [...]
Yong Liu, David Wenhua Bi, Arnaud Magrez
doaj   +1 more source

Calcium and Strontium Coordination Polymers as Controlled Delivery Systems of the Anti-Osteoporosis Drug Risedronate and the Augmenting Effect of Solubilizers

Applied Sciences, 2021
Bisphosphonates (BPs) constitute a class of drugs used for the treatment of calcium- and bone-related disorders, including osteoporosis, Paget’s disease, etc.
Maria Vassaki, Christina Kotoula, Petri Turhanen, Duane Choquesillo-Lazarte, Konstantinos D. Demadis   +4 more
doaj   +1 more source

A cellular automata modelling of dendritic crystal growth based on Moore and von Neumann neighbourhood [PDF]

, 2008
An important step in understanding crystal growth patterns involves simulation of the growth processes using mathematical models. In this paper some commonly used models in this area are reviewed, and a new simulation model of dendritic crystal growth ...
Billings, S.A., Coca, D., Zhao, Y.
core  

Faceting and branching in 2D crystal growth [PDF]

, 2011
The official published version of the Article can be accessed from the link below - Copyright @ 2011 APSUsing atomic scale time-dependent density functional calculations we confirm that both diffusion-controlled and diffusionless crystallization modes ...
Gyula I. Tóth, György Tegze, J. G. Ojalvo, László Gránásy   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Numerical Analysis of the Combined Influence of Accelerated Crucible Rotation and Dynamic Crucible Translation on Liquid Phase Diffusion Growth of SiGe

Crystals, 2016
The effects of accelerated crucible rotation technique (ACRT) and dynamic translation on liquid phase diffusion (LPD) growth of SixGe1−x single crystals have been separately investigated numerically in earlier works and were found to have a very positive
Mandeep Sekhon, Brian Lent, Yanbao Ma
doaj   +1 more source

The effects of polydispersity and metastability on crystal growth kinetics

, 2013
We investigate the effect of metastable gas-liquid (G-L) separation on crystal growth in a system of either monodisperse or slightly size-polydisperse square well particles, using a simulation setup that allows us to focus on the growth of a single ...
Anderson, Bartlett, Buzzacchi, Byelov, Carnahan, Choi, Dixit, Evans, Evans, Evans, Evans, Evans, Evans, Evans, Fantoni, Fasolo, Fortini, Haas, Haas, Hall, John J. Williamson, Liddle, Liu, Martin, Martin, Onsager, Pagonabarraga, Poon, Poon, Prasad, R. Mike L. Evans, Renth, Schöpe, Sollich, Sollich, Stell, Stukowski, ten Wolde, Tirado-Miranda, Trokhymchuk, Warren, Weysser, Wilding, Williams, Williamson, Zaccarelli   +45 more
core   +1 more source

Heteroepitaxial growth of ZnO branches selectively on TiO2 nanorod tips with improved light harvesting performance [PDF]

, 2011
A seeded heteroepitaxial growth of ZnO nanorods selectively on TiO2 nanorod tips was achieved by restricting crystal growth on highly hydrophobic TiO2 nanorod film surfaces.
Gai, Lili, Gu, Feng, Li, Chunzhong, Schmidt-Mende, Lukas, Shao, Wei   +4 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source