Results 21 to 30 of about 5,223,875 (168)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Parallel nondeterministic programming as a language extension in ableC

, 2019
The Silver sources files and sample applications using the language extension. Both files contain same data in different formats.This is an ableC language extension for parallel nondeterministic programming.
Kramer, Lucas, Van Wyk, Eric
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Search for Wellness Through Ancestral Languages

KULA
This video combines visual storytelling and orature to present the findings of a study examining the relationship between speaking Ancestral Languages and individual and communal well-being.
Velvalee Georges, Davina Rousell, Crystal Wood, Sherryl Sewepagaham, Joline Bull, Elmer Ghostkeeper, Doreen Frencheater, Molly Chisaakay, Mary Cardinal-Collins, Earl Wood, Lawrence Berland, Carla Chisaakay, Sharlene Alook, Tabilaah   +13 more
doaj   +1 more source

Datalog as a parallel general purpose programming language [PDF]

, 2010
The increasing available parallelism of computers demands new programming languages that make parallel programming dramatically easier and less error prone.
Cleary, John G., Clayton, Roger, Utting, Mark   +2 more
core  

Exploiting parallelism in coalgebraic logic programming [PDF]

, 2014
We present a parallel implementation of Coalgebraic Logic Programming (CoALP) in the programming language Go. CoALP was initially introduced to reflect coalgebraic semantics of logic programming, with coalgebraic derivation algorithm featuring both ...
Schmidt, Martin, Heras, Jonathan, Heras, J. [0000-0003-4775-1306], Komendantskaya, Ekaterina, Komendantskaya, E. [0000-0002-3240-0987], Schmidt, M., Heras, J., Komendantskaya, E.   +7 more
core   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

A Programming System for End-user Functional Programming [PDF]

This research involves the construction of a programming system, HASKEU, to support end-user programming in a purely functional programming language.
Alam, Abu S
core   +2 more sources

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source