Results 111 to 120 of about 19,858,126 (398)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
3-Methylbenzo[1,2-c:5,4-c′]dichromen-6(8H)-one
Acta Crystallographica Section E, 2014 The title compound, C21H14O3, crystallizes with eight independent molecules (A–H) in the asymmetric unit which are arranged in four groups of two molecules each (AB, CD, EF and GH). In each molecule, the pyran-2-one ring is planar (r.m.s. deviations vary
M. Kayalvizhi +3 more
doaj +1 more source
NMR Crystallography as a Vital Tool in Assisting Crystal Structure Determination from Powder XRD Data [PDF]
, 2022 Kenneth D. M. Harris
openalex +1 more source
THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL
Nature, 2011 Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is ...
J. Payandeh +3 more
semanticscholar +1 more source
Preparation and Crystal Structure Characterization of Li(1+x)mn2o4 [PDF]
, 2010 Li(1+x)Mn2O4 powder has been prepared with starting material of Li2CO3 as lithium source and MnO2 as manganese source. The preparation was done by powder metallurgy with varying Li addition in weight% of 5%, 10%, 15% and 30%.
Wigayati, E. M. (Etty)
core
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
(2E)-2-Benzylidene-9-phenyl-3,4-dihydroacridin-1(2H)-one
Acta Crystallographica Section E, 2014 In the title compound, C26H19NO, the plane of the aromatic heterocycle makes a dihedral angle of 75.22 (4)° with that of the attached phenyl ring. In the crystal, molecules are connected by C—H...O interactions, generating R22(12) dimers.
T. Vinuchakkaravarthy +3 more
doaj +1 more source
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
Nature, 2012 Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many undesirable side effects (sedation, apnoea and ...
A. Manglik +9 more
semanticscholar +1 more source
Synthesis and Characterization of platinum – selenium Derivatives: X-ray Structure of \u3cem\u3etrans\u3c/em\u3e-Pt(Pet\u3csub\u3e3\u3c/sub\u3e)\u3csub\u3e2\u3c/sub\u3e(SePh)\u3csub\u3e2\u3c/sub\u3e [PDF]
, 2007 The crystal structure of trans-[((bis)triethylphosphine)(bis(phenylselenato))platinum (II)] has been determined by single crystal X-ray diffraction. Crystallization occurs in the triclinic space group P-1 (No. 2) with a = 8.9964(2) Å, b = 11.5103(2) Å, c
Lindeman, Sergey V., Rudd, Martin D.
core +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source