Results 21 to 30 of about 14,171 (215)

The intrinsic stiffness of human trabecular meshwork cells increases with senescence. [PDF]

, 2015
Dysfunction of the human trabecular meshwork (HTM) plays a central role in the age-associated disease glaucoma, a leading cause of irreversible blindness.
Chang, Yow-Ren, Morgan, Joshua T, Murphy, Christopher J, Raghunathan, Vijay Krishna, Russell, Paul   +4 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Methods to study microbial adhesion on abiotic surfaces [PDF]

, 2015
Microbial biofilms are a matrix of cells and exopolymeric substances attached to a wet and solid surface and are commonly associated to several problems, such as biofouling and corrosion in industries and infectious diseases in urinary catheters and ...
An YH, Friedman RJ, Bland R, Chen H, Jewell W, et al., Busscher HJ, van der Mei HC, Cos P, Tote K, Horemans T, et al., Costerton JW, Lewandowski Z, Caldwell DE, et al., de Schryver P, Crab R, Defoirdt T, et al., Donlan RM, Costerton JW, Dunne WM, Englebienne P, Hoonacker AV, Verhas M, Fux CA, Shirtliff M, Stoodley P, et al., Garrett TR, Bhakoo M, Zhang Z, Hermansson M, Honraet K, Goetghebeur E, Nelis HJ, Janczuk B, Chibowski E, Bruque J et al., Kumar S, Wittmann C, Heinzle E, Logan BE, Regan JM, Mü, Morikawa M, Ozkan A, Berberoglu H, Peeters E, Nelis HJ, Coenye T, Pereira A, Mendes J, Melo LF, Pereira A, Mendes J, Melo LF, Qureshi N, Annous BA, Ezeji TC, et al., Qureshi N, Maddox I, Seghezzo L, Zeeman G, van Lier JB, et al., Shi X, Zhu X, Simõ, Simõ, Simõ, Simõ, Sobeck DC, Higgins MJ, Stepanović, Stepanović, Stoodley P, Sauer K, Davies D, et al., Todhanakasem T, Sangsutthiseree A, Areerat K, et, van Oss C, van Oss C, Chaudhury M, Good R, van Oss C, Ju L, Chaudhury M et al., van Oss CJ, van Oss CJ, Good RJ, Chaudhury MK, Vesterlund S, Paltta J, Karp M, et al., Watnick P, Kolter R   +41 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Metals in the shell of Bathymodiolus azoricus from a hydrothermal vent site on the Mid-Atlantic Ridge [PDF]

, 2007
Specimens of the mussel Bathymodiolus azoricus were collected from Menez Gwen, a relatively shallow (850 m) hydrothermal vent field on the Mid-Atlantic Ridge. Each bivalve shell (n = 21) was individually cleaned by selective chemical.
Bebianno, Maria João, Catarina Almeida, Ana, Company, Rui, Cosson, R.P., Cravo, Alexandra, Foster, P.   +5 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Miscellaneous studies [PDF]

, 1958
MISCELLANEOUS STUDIES, which includes the following papers: "Geology of the Area in and Around the Jim Woodruff Reservoir" by Charles W. Hendry, Jr. and J.
Hendry, Charles W., Lund, Ernest H., Lund, Ernest H.   +2 more
core  

Kant's philosophy of the aesthetic and the philosophy of praxis [PDF]

, 2012
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2012 Association for Economic and Social Analysis.This essay seeks to reconstruct the terms for a more productive engagement with Kant ...
Adorno T., Bourdieu P., Brecht B., Darden L, Eagleton T., Helfer M. B., Kant I, Karatani K., Lukács G, Marx K., Mike Wayne, Žižek S.   +11 more
core   +1 more source