Results 41 to 50 of about 14,171 (215)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Expression of Functional Recombinant Mussel Adhesive Protein Mgfp-5 in Escherichia coli [PDF]

Mussel adhesive proteins have been suggested as a basis for environmentally friendly adhesives for use in aqueous conditions and in medicine. However, attempts to produce functional and economical recombinant mussel adhesive proteins (mainly foot protein
CHA, HYUNG JOON, Hwang, DS, Jong Hyub Jun, MOON, WON KYU, Yoo Hyo Jin   +4 more
core   +1 more source

Transcriptome analysis of Streptococcus gordonii Challis DL1 indicates a role for the biofilm-associated fruRBA operon in response to Candida albicans [PDF]

, 2016
Multiple levels of interkingdom signaling have been implicated in maintaining the ecological balance between Candida albicans and commensal streptococci to assure a state of oral health.
Brittan, Jane L, Jenkinson, Howard F, Jesionowski, A M, Mansfield, J M, Vickerman, M Margaret   +4 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Acidic Extracellular pH Promotes Activation of Integrin αvβ3 [PDF]

, 2010
Acidic extracellular pH is characteristic of the cell microenvironment in several important physiological and pathological contexts. Although it is well established that acidic extracellular pH can have profound effects on processes such as cell adhesion
A Koide, A Smith, AL Frelinger, AP Mould, AP Mould, AP Mould, AP Mould, AW Schuttelkopf, B Mallik, B-H Luo, BD Harms, BH Luo, C Stock, C Stock, C Stock, CL Schreiner, CV Serrano Jr, D Valdramidou, Douglas A. Lauffenburger, DS Rhoads, E Lindahl, E Puklin-Faucher, E Tzima, EG Alexov, EK Rofstad, F Li, FG Giancotti, G Helmlinger, GA Dunn, GE Plopper, GR Martin, J Chen, J Chen, J Srivastava, J Takagi, J Takagi, J Tan, J-P Xiong, Jean Kanellopoulos, JL Wike-Hooley, K Glunde, Krystyn J. Van Vliet, L Faff, L Schneider, L Stüwe, ML Bajt, N Pampori, PA DiMilla, PP Lehenkari, R Krishnan, Ranjani K. Paradise, RB Dickinson, RE Georgescu, RJ Gillies, RO Hynes, S Grinstein, S Palecek, S Tadokoro, SL Gupton, SP Palecek, X Zhang, Y Kato   +61 more
core   +4 more sources

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A Review of Mathematical Models for the Formation of\ud Vascular Networks [PDF]

, 2012
Mainly two mechanisms are involved in the formation of blood vasculature: vasculogenesis and angiogenesis. The former consists of the formation of a capillary-like network from either a dispersed or a monolayered population of endothelial cells ...
Bell, C. G., Preziosi, L., Scianna, M.
core  

O-mannosylation in Candida albicans enables development of interkingdom biofilm communities [PDF]

, 2014
Peer reviewedPublisher ...
Aqeel Alawfi, Sami, Dutton, Lindsay C, Jenkinson, Howard F, Jepson, Katy, Jepson, Mark A, Lamont, Richard J, Munro, Carol A, Nobbs, Angela H, Vickerman, M Margaret   +8 more
core   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source