Results 1 to 10 of about 59,273,768 (251)

NDM-1 Carbapenemase-Producing Enterobacteriaceae Are Highly Susceptible to Ceragenins CSA-13, CSA-44, and CSA-131 [PDF]

Infection and Drug Resistance, 2020
Treatment of infections caused by NDM-1 carbapenemase-producing Enterobacteriaceae (CPE) represents one of the major challenges of modern medicine. In order to address this issue, we tested ceragenins (CSAs - cationic steroid antimicrobials) as promising agents to eradicate various NDM-1-producing Gram-negative enteric rods.Susceptibility to CSA-13 ...
Łukasz Suprewicz, Krzysztof Fiedoruk, Robert Bucki   +2 more
exaly   +9 more sources

Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings [PDF]

Pathogens, 2022
Recurrent oral infections, as manifested by endodontic and periodontal disease, are often caused by Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans). Here, we assessed the anti-biofilm activity of ceragenin CSA-44 against these microbes growing as a biofilm in the presence of saliva on the surface of human teeth and dental ...
Joanna Tokajuk, Piotr Deptuła, Sylwia J Chmielewska, Karol Skłodowski, Żaneta A Mierzejewska, Małgorzata Grądzka-Dahlke, Adam Tołstoj, Tamara Daniluk, Paulina Paprocka, Paul B Savage, Robert Bucki   +10 more
europepmc   +6 more sources

Bactericidal activity of ceragenin CSA-13, CSA-44 and CSA-131 against bacteria causing bloodstream infections [PDF]

Frontiers in Microbiology
IntroductionThe constantly growing resistance of bacteria causing bloodstream infections and the lack of alternative antibiotics generate the need to develop new therapeutic strategies. In this study, the antibacterial properties of synthetic cholic acid derivatives ceragenins CSA-13, CSA-44 and CSA-131, custom-synthesized peptides human cathelicidin ...
Mańkowska, Angelika, Paprocka, Paulina, Łukasz Suprewicz, Lesiak, Agata, Fortunka, Kamila, Król, Grzegorz, Spałek, Jakub, Okła, Sławomir, Durnaś, Bonita, Tamara Daniluk, Ewelina Piktel, Savage, Paul, Robert Bucki   +12 more
europepmc   +6 more sources

Investigation of the in Vitro Antifungal and Antibiofilm Activities of Ceragenins CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 Against Candida Species [PDF]

Diagnostic Microbiology and Infectious Disease, 2018
Cationic steroid antimicrobials (CSA-ceragenin) are a new class of antimicrobial agent. In vitro activities of CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 and amphotericin B (AMP-B) were assessed against 50 nonrepeat Candida spp. isolates MICs, MFCs and combination studies were determined.
Paul B Savage, Mayram Hacıoğlu, Çağla Bozkurt-Güzel   +2 more
exaly   +6 more sources

VANKOMİSİN DİRENÇLİ ENTEROCOCCUS FAECALIS İZOLATLARI ÜZERİNDE KATYONİK STEROİD ANTİBİYOTİK CSA-44’ÜN ANTİMİKROBİYAL VE ANTİBİYOFİLM AKTİVİTESİNİN İNCELENMESİ [PDF]

ANKEM Dergisi
Günümüz kliniklerinde oldukça korkulan bir etken olmaya başlayan Enterococcus faecalis, bu özelliklerini gösterdikleri yüksek antibiyotik direncine borçludur. Ağır antibiyotik stresine maruz kalmalarına rağmen bu direnç özellikleri sayesinde yaşamlarına devam ederek sağaltımı zor enfeksiyonlara neden olmaktadırlar.
Yamaç Tekintaş, İsmail Öztürk, Aybala Temel, Süreyya Gül Yurtsever, Mine Hoşgör Limoncu   +4 more
openaire   +5 more sources

Comparison of efficacy and safety among four therapeutic regimens in primary membranous nephropathy with high anti-PLA2R antibody titers: a single-center retrospective cohort study. [PDF]

BMC Nephrol
Background Patients with primary membranous nephropathy (PMN) and high anti-PLA2R antibody titers (> 150 RU/mL) often respond poorly to conventional treatments, and the optimal immunosuppressive regimen remains unclear. We conducted a retrospective study
Huang Y, Meng X, Wu S, Miao X, Qin L, Zhang K, Sun J, Wang J.   +7 more
europepmc   +2 more sources

Evaluation of Cytotoxicity, Antimicrobial, and Antifungal Properties of Ceragenins CSA-44 and CSA-131

Abstract A novel family of antimicrobial drugs is known as cationic steroid antimicrobials (CSA-ceragenin), which includes CSA44 and CSA 131. This work aimed to examine the antibacterial and antimycotic properties of CSA44 and CSA 131 against Staphylococcus aureus, methicillin-resistant S.
Kubra Aslantas, Cihan Oz, Ali Taghizadehghalehjoughi, Sidika Genc, Aziz Sahin Erdogan, Paul B. Savage, Mehmet Cemal Adiguzel   +6 more
openaire   +1 more source

Paraspinal Muscle Quality and Functional Outcomes Following Lumbar Fusion: A Systematic Review. [PDF]

Musculoskeletal Care
ABSTRACT Purpose Lumbar interbody fusion (LIF) procedures are associated with postoperative paraspinal muscle atrophy and fatty infiltration (FI), which may influence long‐term pain and functional recovery. However, the relationship between muscle quality, both pre‐ and postoperatively, and patient‐reported outcomes remains unclear for patients ...
Tu T, Kelhofer N, Cheng C, Shrestha R, Huang L, Jan YK.   +5 more
europepmc   +2 more sources

Re-examining the Concordance Between Child Abuse Reported by Youth and Casefile Records. [PDF]

J Clin Child Adolesc Psychol
Lombera MA, Shenk CE, Senich KL, Crockett N.   +3 more
europepmc   +1 more source

Clinical prediction models in cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis. [PDF]

Crit Care
Lasa-Berasain P, Torrecilla Ugarte A, Juárez-Vela R, Ibánez-Beróiz B, Ansotegui Hernández A, Sádaba R, Barado Hualde J.   +6 more
europepmc   +1 more source