Results 51 to 60 of about 59,273,768 (251)

Permeability of Intact and De-Epithelialised, Human Vaginal Mucosa to Tacrolimus and Cyclosporin A

European Journal of Inflammation, 2007
Immunosuppressants may be applied topically to mucosal surfaces for treating inflammatory diseases, e.g. vulvar lichen planus and Behçet's disease. The efficacy of the treatment is dependent on the potency of the drug and its penetration into the tissue.
L.M. Moll, A.D. Van Eyk, P. Van Der Bijl
doaj   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source

Santé mentale et bien-être pour les étudiants du postsecondaire

, 2020
Document available for free on CSA Group's website for residents of Canada.Disponible en français dans EDUQ.info sous le titre "Santé mentale et bien-être pour les étudiants du postsecondaire"

core   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

What Prohibit CSA Membership Renewals? Identifying Barriers of CSA Participation [PDF]

, 2018
Community Supported Agriculture (CSA) serves as platform for local producers, especially for small size farms, to sell local fresh products directly to local residents. Joining CSA will benefit the local economy as well as the local agriculture. Although
Zhang, Lisha, Gao, Zhifeng, Chen, Junhong   +2 more
core   +1 more source

Insights into the chemical basis for the impact of ceragenin and derivative compounds on the mechanical performance of medical adhesive formulations

Discover Applied Sciences
An approach to reducing and preventing surgical site infections (SSI) is to incorporate an antimicrobial compound into the formulation of medical adhesives.
Shane M. Drake, Caleb D. Potter, Aaron L. Zaugg, Melissa N. Lumogdang, Daniel J. Pendleton, Jacob R. Orchard, Paul B. Savage, James E. Patterson   +7 more
doaj   +1 more source

MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine.

PLoS ONE, 2014
ObjectivesIn cases of "spina bifida," a detailed prenatal imaging assessment of the exact morphology of neural tube defects (NTD) is often limited. Due to the diverse clinical prognosis and prenatal treatment options, imaging parameters that support the ...
Ramona Woitek, Anton Dvorak, Michael Weber, Rainer Seidl, Dieter Bettelheim, Veronika Schöpf, Gabriele Amann, Peter C Brugger, Julia Furtner, Ulrika Asenbaum, Daniela Prayer, Gregor Kasprian   +11 more
doaj   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Carpal tunnel syndrome assessment with ultrasonography: value of inlet-to-outlet median nerve area ratio in patients versus healthy volunteers. [PDF]

PLoS ONE, 2015
To evaluate the diagnostic value of the Inlet-to-outlet median nerve area ratio (IOR) in patients with clinically and electrophysiologically confirmed carpal tunnel syndrome (CTS).Forty-six wrists in 46 consecutive patients with clinical and ...
Tengfei Fu, Manlin Cao, Fang Liu, Jiaan Zhu, Dongmei Ye, Xianxuan Feng, Yiming Xu, Gang Wang, Yuehong Bai   +8 more
doaj   +1 more source