Results 61 to 70 of about 951 (159)

Hypotaurine Reduces Glucose‐Mediated Vascular Calcification

Acta Physiologica, Volume 241, Issue 8, August 2025.
ABSTRACT Aim Vascular calcification (VC), a characteristic feature of peripheral artery disease in patients with diabetes and chronic kidney disease, has been associated with poor prognosis. We hypothesize that hyperglycemia drives VC through alterations in metabolomic and transcriptomic profiles. Methods Human coronary artery smooth muscle cells (SMCs)
Marina A. Heuschkel, Armand Jaminon, Steffen Gräber, Anna Artati, Jerzy Adamski, Joachim Jankowski, Leon Schurgers, Nikolaus Marx, Willi Jahnen‐Dechent, Claudia Goettsch   +9 more
wiley   +1 more source

Exploring Herding in Capital Structure Choices: Insights From Developed European Economies

Journal of Corporate Accounting &Finance, Volume 36, Issue 3, Page 378-393, July 2025.
ABSTRACT This paper investigates the potential influence of herd behavior on companies' capital structure choices. While existing capital structure theories often overlook psychological and social factors, this study explores the role of herding, an area under‐examined in the literature.
Zrinka Lovretin Golubić, Ena Pecina, Zrinka Orlović   +2 more
wiley   +1 more source

An Examination of Herding Behavior in Chinese A-Share Market by Cross-Sectional Absolute Deviation (CSAD)

Modern Economy, 2020
The study aims to test the existence and the continuity of herding behaviour in Chinese A-share market by the method called cross-sectional absolute deviation (CSAD). Herding behavior, defined as individuals tend to follow others when making decision, has a large impact on stock markets.
openaire   +2 more sources

Genome-Wide Association Study Confirming a Strong Effect of HLA and Identifying Variants inCSAD/lnc-ITGB7-1on Chromosome 12q13.13 Associated With Susceptibility to Fulminant Type 1 Diabetes [PDF]

Diabetes, 2018
The first genome-wide association study of fulminant type 1 diabetes was performed in Japanese individuals. As previously reported using a candidate gene approach, a strong association was observed with multiple single nucleotide polymorphisms (SNPs) in the HLA region, and the strongest association was observed with rs9268853 in the class II DR region (
Yumiko Kawabata, Nao Nishida, Takuya Awata, Eiji Kawasaki, Akihisa Imagawa, Akira Shimada, Haruhiko Osawa, Shoichiro Tanaka, Kazuma Takahashi, Masao Nagata, Hisafumi Yasuda, Yasuko Uchigata, Hiroshi Kajio, Hideichi Makino, Kazuki Yasuda, Tetsuro Kobayashi, Toshiaki Hanafusa, Katsushi Tokunaga, Hiroshi Ikegami   +18 more
openaire   +2 more sources

Taurine Alleviates Pancreatic β‐Cell Senescence by Inhibition of p53 Pathway

Journal of Diabetes, Volume 17, Issue 6, June 2025.
Taurine in β cell senescence. ABSTRACT Background Pancreatic β‐cells function deteriorates during aging, leading to increased risk of type 2 diabetes. We and others previously demonstrated that p53 activation triggers β‐cell senescence and dysfunction in aging, but how its activity is controlled remains incompletely understood. Metabolites are not only
Baomin Wang, Ziyan Wang, Yumei Yang, Melody Yuen Man Ho, Runyue Yang, Huizi Yang, Siyi Liu, Huige Lin, Kenneth King Yip Cheng, Xiaomu Li   +9 more
wiley   +1 more source

The Prebiotic Effect of Kaempferol in Regulating Bile Acid Metabolism

Food Science &Nutrition, Volume 13, Issue 3, March 2025.
Kaempferol (Kae) can suppress the expression of CYP7A1, while increasing the CYP27A1 and UGTs expression by activating the liver FXR. Kae modulates the BA profile by decreasing the BSH activities. Kae markedly increases the abundance of beneficial bacteria and inhibits the growth of pathogenic bacteria.
Xiaoyan Li, Guoxin Huang, Imran Khan, Zhishan Ding, Wen Luan Wendy Hsiao, Zhongqiu Liu   +5 more
wiley   +1 more source

Pricing dynamics and herding behaviour of NFTs

European Financial Management, Volume 31, Issue 2, Page 670-710, March 2025.
Abstract This paper analyzes the sales of 875,389 art nonfungible tokens (NFTs) on the Ethereum blockchain to identify the key determinants influencing NFT pricing and market dynamics. We find that market liquidity and trade volume are strong predictors of NFT prices. Contrarily, social media activity negatively correlates with prices.
Gilbert Fridgen, Roman Kräussl, Orestis Papageorgiou, Alessandro Tugnetti   +3 more
wiley   +1 more source

Acrylamide induces spatiotemporal metabolic profiling disturbance via targeting taurine and hypotaurine metabolism during early zebrafish development

Food Frontiers, Volume 6, Issue 1, Page 282-299, January 2025.
This study provides in‐depth evidence on the metabolic regulation of zebrafish embryos with acrylamide exposure at different zebrafish developmental stages. The pattern of significantly changed metabolites revealed that acrylamide exposure has a detrimental effect on early heart development in zebrafish due to the inhibition of de novo synthesis of ...
Anli Wang, Jia Zeng, Xiaoran Song, Yingyu Huang, Jianxin Yao, Li Zhu, Yuchen Gao, Binjie Wang, Yuanzhao Wu, Zhongshi Xu, Ruonan Zheng, Yazhou Qin, Jiye Wang, Weixuan Yao, Xuzhi Wan, Haoyu Li, Pan Zhuang, Jingjing Jiao, Shulin Zhuang, Yu Zhang   +19 more
wiley   +1 more source

Characterization of the PLP-dependent decarboxylases GADL1 and CSAD

, 2022
Pyridoxal 5’-phosphate (PLP) -dependent enzymes constitute an essential superfamily of enzymes for all living organisms. Due to the chemistry of their cofactor, PLP, these enzymes catalyze a wide variety of reactions. PLP-dependent decarboxylases (PLPDCs) play key roles in amino acid metabolism and are considered important biocatalysts for the ...
openaire   +1 more source

Research on the Antiaging Activity of Licorice Water Extract in Aging Mice via Antioxidation, Neuronal Protection, Gut Microbiota Restoration, and PI3K/AKT/mTOR Modulation

Mediators of Inflammation, Volume 2025, Issue 1, 2025.
Background Aging is a multifaceted physiological process characterized by progressive multiorgan dysfunction, oxidative stress, neuronal injury, cognitive impairment, and alterations in gut microbiota composition. Licorice, a widely used traditional medicinal herb, contains diverse bioactive constituents; however, its overall antiaging properties and ...
Yanhua Yu, Baiji Xue, Tong Liu, Xianwen Yue, Dawei Liu, Xia Yu, Yang Xu, Xueliang Zhao, Xuefeng Li, Palash Mandal   +9 more
wiley   +1 more source