Results 11 to 20 of about 2,177 (207)

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR [PDF]

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +3 more sources

CSAKD: Determining Absolute Ligand Affinities From 19F NMR Chemical Shift Anisotropy [PDF]

Angewandte Chemie, Volume 138, Issue 33, 10 August 2026.
Affinity determination is crucial in drug discovery, yet remains difficult for weakly binding fragments. We introduce chemical shift anisotropy KD$K_{\text{D}}$ (CSAKD) by 19F$^{19}{\rm F}$ NMR relaxation experiments, a titration‐free method that requires no isotopic labeling.
Simon H. Rüdisser, Gabriela Stadler, Alvar D. Gossert   +2 more
wiley   +3 more sources

CSAR: a contig scaffolding tool using algebraic rearrangements [PDF]

Bioinformatics, 2017
Abstract Summary Advances in next generation sequencing have generated massive amounts of short reads. However, assembling genome sequences from short reads still remains a challenging task. Due to errors in reads and large repeats in the genome, many of current assembly tools usually produce just ...
Kun-Tze Chen, Chia-Liang Liu, Shang-Hao Huang, Hsin-Ting Shen, Yi-Kung Shieh, Hsien-Tai Chiu, Chin Lung Lu   +6 more
openaire   +4 more sources

Integration of Ligand and Structure Based Approaches for CSAR-2014 [PDF]

Journal of Chemical Information and Modeling, 2015
The prediction of binding poses and affinities is an area of active interest in computer-aided drug design (CADD). Given the documented limitations with either ligand or structure based approaches, we employed an integrated approach and developed a rapid protocol for binding mode and affinity predictions.
Philip Prathipati, Kenji Mizuguchi
openaire   +5 more sources

Engineering and Tuning of High Quality Hexagonal Boron Nitride Nanophotonic Resonators [PDF]

Small, Volume 22, Issue 47, 21 August 2026.
The manuscript explores nanofabrication protocols for photonic crystal cavities and microdisk resonators from hexagonal boron nitride. High Q cavities are fabricated and their resonances are controllably tuned. The work is important for future realization of quantum technologies with hexagonal boron nitride.
Otto Cranwell Schaeper, Angus Gale, Nathan Coste, Dominic Scognamiglio, Jonathan Horder, Hugo Quard, Igor Aharonovich   +6 more
wiley   +2 more sources

GPU-Optimized Implementation for Accelerating CSAR Imaging

Electronics
The direct porting of the Range Migration Algorithm to GPUs for three-dimensional (3D) cylindrical synthetic aperture radar (CSAR) imaging faces difficulties in achieving real-time performance while the architecture and programming models of GPUs significantly differ from CPUs.
Mengting Cui, Ping Li, Zhaohui Bu, Meng Xun, Li Ding   +4 more
openaire   +2 more sources

A Focusing Method of Buildings for Airborne Circular SAR

Remote Sensing
Airborne circular synthetic aperture radar (CSAR) can realize high-resolution imaging of the scene over 360 degrees azimuth angle variation. Aiming at the problem of focusing of buildings for the airborne CSAR, this paper first analyzes the phase errors ...
Dong Feng, Daoxiang An, Jian Wang, Leping Chen, Xiaotao Huang   +4 more
doaj   +2 more sources

Assessment and quantitative analysis of hip surrounding muscles in children with developmental dysplasia of the hip via magnetic resonance imaging [PDF]

Journal of Orthopaedic Surgery and Research
Background The muscles that encase the hip serve a crucial role in both joint stability and functional efficacy, and as developmental dysplasia of the hip (DDH) progresses, the surrounding musculature may undergo specific adaptations that reduce joint ...
Lian Duan, Weizheng Zhou, Lianyong Li
doaj   +2 more sources

A GAN-based fast focusing method for circular SAR images [PDF]

Heliyon
Circular Synthetic Aperture Radar(CSAR) imaging is vulnerable to perturbations in the atmosphere and various other elements that can lead to position offset errors in the antenna's phase center as well as induce motion errors.
Bingxuan Li, Yanheng Ma, Lina Chu, Wei Li, Yuanping Shi   +4 more
doaj   +2 more sources

A Novel Building Extraction Method for Airborne L-Band CSAR Images Based on Fusion of Scattering Statistical Characteristics

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Circular synthetic aperture radar (CSAR), as a novel imaging mode, enables multiaspect imaging of the same scene, capturing scattering information from different azimuth angles, thereby significantly enhancing the performance of SAR image interpretation.
Xiaodong Yan, Leping Chen, Li Xiao, Daoxiang An   +3 more
doaj   +2 more sources