Results 51 to 60 of about 140,914 (328)

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

Advanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan, Haitao Yuan, Wenjun Zhu, Xiaokang Xie, Shen Zhou, Wenzhi Hao, Xiaowei Mo, Lian Yang, Xiaojuan Li, Junshan Liu, Lijuan Deng, Jiaxu Chen   +11 more
wiley   +1 more source

Predicting and Rationalizing Piezoelectricity in Racemic Bioorganic Molecular Crystals

Angewandte Chemie, EarlyView.
Racemic molecular crystals, composed of equal mixtures of chiral enantiomeric components, are predicted to exhibit significant piezoelectric responses and favourable mechanical flexibility. This study identifies organic and bioorganic racemates as promising candidates for sustainable, lead‐free materials, enabling next‐generation applications in energy
Shubham Vishnoi, Sarah Guerin
wiley   +2 more sources

Harnessing hydrogen-bonding: advancements and applications in pharmaceutical co-crystallization

Journal of Applied Pharmaceutical Research
Background: In the context of supramolecular chemistry, the formation of solid-state structures that exhibit predictable form and function through the use of intermolecular interactions is known as crystal engineering.
Preeti Devi, Sonali Kakkar, Vikas Budhwar, Manjusha Choudhary, Vikas Jogpal   +4 more
doaj   +1 more source

Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution

NeuroImage: Clinical, 2018
Parkinson's disease (PD) is a progressive neurodegenerative disorder that affects extensive regions of the central nervous system. In this work, we evaluated the structural connectome of patients with PD, as mapped by diffusion-weighted MRI tractography ...
Koji Kamagata, Andrew Zalesky, Taku Hatano, Maria Angelique Di Biase, Omar El Samad, Shinji Saiki, Keigo Shimoji, Kanako K. Kumamaru, Kouhei Kamiya, Masaaki Hori, Nobutaka Hattori, Shigeki Aoki, Christos Pantelis   +12 more
doaj   +1 more source

CSD: Discriminance with Conic Section for Improving Reverse k Nearest Neighbors Queries

, 2020
The reverse $k$ nearest neighbor (R$k$NN) query finds all points that have the query point as one of their $k$ nearest neighbors ($k$NN), where the $k$NN query finds the $k$ closest points to its query point. Based on the characteristics of conic section,
Bai, Mingyuan, Gao, Junbin, Li, Yang, Liu, Gang, Ming, Zi, Ye, Lixin   +5 more
core  

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Interlinking securities settlement systems: a strategic commitment? [PDF]

Central securities depositories (CSDs) have opened mutual links, but most of them are seldom used. Why are idle links established? By allowing a foreign CSD to offer services through the link the domestic CSD invites competition.
Kauko, Karlo
core   +3 more sources

Drain vs. no-drain for acetabular fractures after treatment via a modified stoppa approach: A retrospective study

Frontiers in Surgery, 2023
ObjectiveThe aim of this study was to compare the clinical efficacy of close suction drainage (CSD) and no-CSD after a modified Stoppa approach for the surgical fixation of acetabular fractures.MethodsThis retrospective study included 49 consecutive ...
Lin Jin, Lin Jin, Zhongzheng Wang, Zhongzheng Wang, Kuo Zhao, Kuo Zhao, Xiaodong Lian, Xiaodong Lian, Wei Chen, Wei Chen, Wei Chen, Yingze Zhang, Yingze Zhang, Yingze Zhang, Yingze Zhang, Zhiyong Hou, Zhiyong Hou, Zhiyong Hou   +17 more
doaj   +1 more source

Ictal epileptic headache. an old story with courses and appeals [PDF]

, 2012
The term "ictal epileptic headache" has been recently proposed to classify the clinical picture in which headache is the isolated ictal symptom of a seizure.
MARTELLETTI, Paolo, NEGRO, ANDREA, PARISI, Pasquale, Pasquale Striano, Vincenzo Belcastro   +4 more
core   +1 more source

Machine Learning for Designing Perovskites and Perovskite‐Inspired Solar Materials: Emerging Opportunities and Challenges

Advanced Science, EarlyView.
This review offers a comprehensive comparison between perovskites and perovskite‐inspired materials (PIMs), focusing on their crystal structures, electronic properties, and chemical compositions. It evaluates the applicability of machine learning (ML) descriptors and models across both material classes.
Yangfan Zhang, Yiming Xia, Ali Shakiba, Hongrui Zhang, Xiaojing Hao, Priyank V. Kumar, Mahesh P. Suryawanshi   +6 more
wiley   +1 more source