Results 81 to 90 of about 140,914 (328)

Different association of gBRCA1 and gBRCA2 variants with HER2-low status in invasive breast cancer: findings from a Ukrainian study

Scientific Reports
HER2-low breast cancer (BC) representing about 40–55% of all BC has emerged as a targetable entity. However, little is known about the link between germline BRCA1/2 mutations (gBRCA1/2) and HER2-low status in BC, especially in Ukrainian population.
Sofiia Livshun, Denys Kozakov, Alina Kruhlykovа, Olena Koshyk, Nazarii Kobyliak, Oleksii Seleznov, Alina Matvieieva, Yaroslav Shparyk, Nataliia Volodko, Victor Zavizion, Anna Khmel, Kateryna Kharchenko, Natalya Otchenash, Alina Andriiv, Oksana Sulaieva   +14 more
doaj   +1 more source

Coupling of capillary RBC flow failure with neuronal depolarization [PDF]

, 2009
RBC (oxygen-carrier) behaviour in the cerebrocortical microvasculature during K^+^-induced cortical spreading depression (CSD) was examined in urethane-anesthetized male Wistar rats (n=10).
Haruki Toriumi, Minoru Tomita, Miyuki Unekawa, Norihiro Suzuki, Yutaka Tomita   +4 more
core   +1 more source

Immune cells in thyroid adenoma and carcinoma: uncovering a hidden value of assessing tumor-host interplay and its potential application in thyroid cytopathology

Frontiers in Molecular Biosciences
IntroductionAlthough the role of tumor immune microenvironment (TIME) in thyroid cancer is well established, little data exists about the differences in immune cell presence in thyroid adenomas and carcinomas.
Iryna Omelianenko, Iryna Omelianenko, Nazarii Kobyliak, Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Falalyeyeva, Oleksii Seleznov, Pavlina Botsun, Lyudmila Ostapchenko, Oleksandr Korotkyi, Liudmyla Domylivska, Olena Tsyryuk, Galyna Mykhalchyshyn, Tetiana Shapochka, Oksana Sulaieva, Oksana Sulaieva   +15 more
doaj   +1 more source

Reduced-Complexity Maximum-Likelihood Detection in Multiple-Antenna-Aided Multicarrier Systems

, 2005
In this contribution we explore a novel Optimized Hierarchy Reduced Search Algorithm (OHRSA)-aided space-time processing method, which may be regarded as an advanced extension of the Complex Sphere Decoder (CSD) method. The algorithm proposed extends the
Akhtman, Jos, Hanzo, Lajos
core  

Efficacy and Safety of Guselkumab in Participants with Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of the Phase 3, Randomized, Placebo‐Controlled SOLSTICE Study

Arthritis &Rheumatology, Accepted Article.
Objective Evaluate the efficacy and safety of guselkumab, an interleukin‐23p19‐subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor inhibitor (TNFi‐IR).
Alexis Ogdie, Joseph F Merola, Philip J Mease, Christopher T Ritchlin, Jose U Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B Gottlieb   +12 more
wiley   +1 more source

The effect of P2X7 antagonism on subcortical spread of optogenetically-triggered cortical spreading depression and neuroinflammation

The Journal of Headache and Pain
Migraine is a neurological disorder characterized by episodes of severe headache. Cortical spreading depression (CSD), the electrophysiological equivalent of migraine aura, results in opening of pannexin 1 megachannels that release ATP and triggers ...
Burak Uzay, Buket Donmez-Demir, Sinem Yilmaz Ozcan, Emine Eren Kocak, Muge Yemisci, Yasemin Gursoy Ozdemir, Turgay Dalkara, Hulya Karatas   +7 more
doaj   +1 more source

Do Corporate Strategies in Fintech and Green Finance Enhance ESG Performance? The Moderating Role of Government Policies

Business Strategy and the Environment, EarlyView.
ABSTRACT Despite the growing interest in ESG performance, limited research explores the mediating role of government policy in the relationship between Fintech, green finance and ESG outcomes. We address this gap by examining how Fintech and green finance influence ESG performance through government policies.
Mandella Osei‐Assibey Bonsu, Samuel Clottey Attuquaye, Katie Hyslop, Ying Wang, Li Kaodui   +4 more
wiley   +1 more source

Change in liking following reduction in sweetness level of carbonated beverages: a randomized controlled parallel trial

Scientific Reports
Despite recommendations to reduce sweet-tasting foods and beverage consumption, there is limited understanding of our ability to adapt to a less sweet diet and the optimal method for doing so.
Eunice Mah, Alison Kamil, Traci M. Blonquist, Colin D. Rehm, Shankang Qu, Philip Stern, Alissa R. Wilson   +6 more
doaj   +1 more source

Intramolecular N···F Pnictogen Bond Mitigates the Explosive Behavior of Azido‐L‐Phenylalanines

ChemistryEurope, EarlyView.
An intramolecular N···F pnictogen bond is the key for the chemical stabilization of the fluorinated azido‐L‐phenylalanines, mitigating the risk of explosion and thus facilitating the handling and storage of these materials. Organic azides are versatile intermediates but are plagued by intrinsic instability and potential explosiveness. Here, it is shown
Andrea Pizzi, Eleonora Veronese, Nicola Demitri, Marco Saccone, Pierangelo Metrangolo, Giancarlo Terraneo   +5 more
wiley   +1 more source

Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice

Journal of Neuroinflammation
This study investigated the role of O-GlcNAc cycling in Alzheimer’s disease-related changes in brain pathophysiology induced by chronic REM sleep deprivation (CSD) in mice.
Dong Yeol Kim, Sang-Min Kim, Inn-Oc Han
doaj   +1 more source