Results 211 to 220 of about 734,560 (306)

Region-specific proteomic profiling of brain interstitial fluid <i>via</i> a micro-invasive sampling platform.

Lab Chip
Cao Q, Jackson HD, Duncan AJ, Cui Y, Higginbotham HO, Lesnik S, Jo Y, Yu J, White FM, Cima MJ.   +9 more
europepmc   +1 more source

Clinical correlates of a negative cerebrospinal fluid α-synuclein seed amplification assay result in Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Mastrangelo A, Wurster I, Ticca A, Lerche S, Zenesini C, Röben B, Mammana A, Hauser AK, Ruggeri E, Deuschle C, Vittoriosi E, Bentivenga GM, Schulte C, Capellari S, Brockmann K, Parchi P.   +15 more
europepmc   +1 more source

Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain

Advanced Science, EarlyView.
A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio, Tommaso Gili, Andrea Gabrielli, Maurizio Mattia   +3 more
wiley   +1 more source

Increased CSF levels of soluble AXL at diagnosis correlate with poor prognosis in patients affected by amyotrophic lateral sclerosis. [PDF]

Brain Commun
Spatafora MG, Dubin J, Domi T, Lombardi R, Cabras P, Dalla Bella E, Consonni M, Quattrini A, Verri M, Lauria G, Van Damme P, Poesen K, Riva N, Peviani M.   +13 more
europepmc   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Ubrogepant Plasma and Cerebrospinal Fluid Exposures in Participants With a History of Migraine: Findings From a Phase 1b Open-Label Trial. [PDF]

Clin Transl Sci
Boinpally RR, Trugman JM.
europepmc   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer's disease continuum. [PDF]

Nat Commun
Collij LE, Salvadó G, Horie K, Barthélemy NR, Betthauser TJ, Strandberg O, Smith R, Palmqvist S, Schindler SE, Ossenkoppele R, Janelidze S, Mattsson-Carlgren N, Bateman RJ, Hansson O.   +13 more
europepmc   +1 more source

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source