Results 41 to 50 of about 50,052 (238)

Failure to pay for social health insurance premiums: Acts of protest or desperation?

Preventive Medicine Reports, 2015
Background: In Switzerland, basic health insurance is mandatory for all inhabitants, but a rising number of insured have arrears in premium payments, potentially leading to coverage suspension.
Viktor von Wyl, Konstantin Beck
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Ambiphilic Ligand Stabilization of Aluminum(I) Fragments: Halides, Cations, and a Hydride

Angewandte Chemie, EarlyView.
Stabilization of elusive aluminum(I) halides in the framework of an ambiphilic ligand is reported. The unique bonding situation at the trigonal‐bipyramidal aluminum center is analyzed, and the coordination chemistry and Al(I)Br transfer reactivity of the complexes are presented.
Charlotte S. V. Weiß, Philipp Dabringhaus   +1 more
wiley   +2 more sources

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source

High‐Efficiency Precipitate Recycling Strategy Paves the Way for Efficient Sb2S3 Solar Cells Fabricated by CBD Method

Advanced Science, EarlyView.
A novel PR strategy was proposed to improve CBD‐derived Sb2S3 film quality. It synergistically optimized the CBO of CdS/Sb2S3 interface and the back‐contact barrier, while the VS2 donor defect was converted into SSb2 acceptor defect with lower concentration.
Yeyang Lin, Zixian Cai, Mingen Zheng, Ye Huang, Weihuang Wang, Qiqiang Zhu, Qing Gao, Jianhui Chen, Shuying Cheng   +8 more
wiley   +1 more source

Oral Delivery Systems for Food‐Derived Bioactive Peptides: Enhancing Stability, Bioavailability, and Health Benefits

Advanced Science, EarlyView.
Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu, Fan Li, Runan Zhao, Tao Shu, Weihong Min, Bei‐Wei Zhu   +5 more
wiley   +1 more source

A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol

BMC Veterinary Research, 2019
Background Epilepsy is the most common brain disease in dogs. Recently, diets have been reported to have a positive impact on seizure activity and behaviour in various species including dogs with idiopathic epilepsy (IE).
Benjamin Andreas Berk, Rowena Mary Anne Packer, Tsz Hong Law, Annette Wessmann, Andrea Bathen-Nöthen, Tarja Susanna Jokinen, Anna Knebel, Andrea Tipold, Ludovic Pelligand, Holger Andreas Volk   +9 more
doaj   +1 more source

Suppressing Morphological and Energetic Disorder in Copper Antimony Sulfide‐based Hole‐Transporting Materials via Ligand–Precursor Engineering for Efficient and Stable Perovskite Solar Cells

Advanced Science, EarlyView.
Sulfur‐precursor and ligand engineering regulate the nucleation, morphology, and energetic disorder of CuSbS2 nanocrystals for dopant‐free inorganic hole‐transport layers in perovskite solar cells. Thiourea‐assisted synthesis combined with optimized OAm/OAc coordination suppresses excessive anisotropic growth, enabling mixed plate‐like/quasi‐spherical ...
Ibrahimhan Dilci, Savas Sonmezoglu
wiley   +1 more source

Optimal Indication of D3 Lymph Node Dissection for Non‐Metastatic Colon Cancers by Tumor Stages: Evaluation of Therapeutic Value Index for Each Lymph Node Station

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aims To explore the therapeutic impact of D3 lymph node dissection for non‐metastatic colon cancers, evaluating the therapeutic value index for each lymph node station according to surgical stages. Methods Consecutive patients with surgical Stage I–III colon and rectosigmoid cancer who underwent curative resection between January 2003 and ...
Akira Ouchi, Kozo Kataoka, Eiji Shinto, Takashi Akiyoshi, Takefumi Yoshida, Yasuyuki Takamizawa, Yukihide Kanemitsu, Hirotoshi Kobayashi, Hideki Ueno, on behalf of the Lymph Nodes Committee of JSCCR   +9 more
wiley   +1 more source