Results 111 to 120 of about 6,578,156 (324)

Classification of COVID-19 patients from chest CT images using multi-objective differential evolution–based convolutional neural networks

European Journal of Clinical Microbiology and Infectious Diseases, 2020
Early classification of 2019 novel coronavirus disease (COVID-19) is essential for disease cure and control. Compared with reverse-transcription polymerase chain reaction (RT-PCR), chest computed tomography (CT) imaging may be a significantly more ...
Dilbag Singh, Vijay Kumar, Vaishali, Manjit Kaur   +3 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CT scan diagnosis of hepatic adenoma in a case of von Gierke disease

Indian Journal of Radiology and Imaging, 2012
Hepatic adenoma is a well-defined, benign, solitary tumor of the liver. In individuals with glycogen storage disease I, adenoma tends to occur at a relatively younger age and can be multiple (adenomatosis).
Bipin Valchandji Daga, Vaibhav R Shah, Rahul B More   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets

Nature Communications, 2020
Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation of CT scans for differentiation of COVID-19 findings from other ...
S. Harmon, Thomas Sanford, Sheng Xu, E. Turkbey, H. Roth, Ziyue Xu, Dong Yang, Andriy Myronenko, Victoria L. Anderson, A. Amalou, Maxime Blain, Michael T Kassin, D. Long, N. Varble, S. Walker, Ulas Bagci, A. Ierardi, Elvira Stellato, G. Plensich, G. Franceschelli, Cristiano Girlando, G. Irmici, Dominic Labella, D. Hammoud, A. Malayeri, E. Jones, R. Summers, P. Choyke, Daguang Xu, Mona G. Flores, Kaku Tamura, H. Obinata, Hitoshi Mori, F. Patella, M. Cariati, G. Carrafiello, P. An, B. Wood, B. Turkbey   +38 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Diagnostic test interpretation and referral delay in patients with interstitial lung disease. [PDF]

, 2019
BACKGROUND:Diagnostic delays are common in patients with interstitial lung disease (ILD). A substantial percentage of patients experience a diagnostic delay in the primary care setting, but the factors underpinning this observation remain unclear.
Adegunsoye, Ayodeji, Boctor, Noelle, Chung, Jonathan H, DiGeronimo, Ryan, Kadoch, Michael, Lafond, Elyse, Oldham, Justin M, Pan, Isabella, Pritchard, David, Pugashetti, Janelle Vu, Sarma, Nandini, Strek, Mary   +11 more
core   +1 more source

Chest CT Features of COVID-19 in Rome, Italy

Radiology, 2020
Background The standard for diagnosis of SARS-CoV-2 virus is reverse transcription polymerase chain reaction (RT-PCR) test, but chest CT may play a complimentary role in the early detection of COVID-19 pneumonia.
D. Caruso, M. Zerunian, M. Polici, F. Pucciarelli, Tiziano Polidori, Carlotta Rucci, Gisella Guido, Benedetta Bracci, C. de Dominicis, A. Laghi   +9 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Diagnostic Performance of CT and Reverse Transcriptase-Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis

Radiology, 2020
Background Recent studies have suggested that chest computed tomography (CT) scans could be used as a primary screening or diagnostic tool for coronavirus disease 2019 (COVID-19) in epidemic areas.
Hyungjin Kim, Hyunsook Hong, S. Yoon
semanticscholar   +1 more source