Results 121 to 130 of about 6,806,803 (376)

Artificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets

Nature Communications, 2020
Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation of CT scans for differentiation of COVID-19 findings from other ...
S. Harmon, Thomas Sanford, Sheng Xu, E. Turkbey, H. Roth, Ziyue Xu, Dong Yang, Andriy Myronenko, V. Anderson, A. Amalou, Maxime Blain, Michael T Kassin, D. Long, N. Varble, S. Walker, Ulas Bagci, A. Ierardi, Elvira Stellato, G. Plensich, G. Franceschelli, Cristiano Girlando, Giovanni Irmici, Dominic Labella, D. Hammoud, A. Malayeri, E. Jones, R. Summers, P. Choyke, Daguang Xu, Mona G. Flores, Kaku Tamura, Hirofumi Obinata, Hitoshi Mori, F. Patella, M. Cariati, G. Carrafiello, P. An, B. Wood, B. Turkbey   +38 more
semanticscholar   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

CT scan diagnosis of hepatic adenoma in a case of von Gierke disease

Indian Journal of Radiology and Imaging, 2012
Hepatic adenoma is a well-defined, benign, solitary tumor of the liver. In individuals with glycogen storage disease I, adenoma tends to occur at a relatively younger age and can be multiple (adenomatosis).
Bipin Valchandji Daga, Vaibhav R Shah, Rahul B More   +2 more
doaj   +1 more source

Chest CT Features of COVID-19 in Rome, Italy

Radiology, 2020
Background The standard for diagnosis of SARS-CoV-2 virus is reverse transcription polymerase chain reaction (RT-PCR) test, but chest CT may play a complimentary role in the early detection of COVID-19 pneumonia.
D. Caruso, Marta Zerunian, M. Polici, F. Pucciarelli, Tiziano Polidori, Carlotta Rucci, Gisella Guido, Benedetta Bracci, C. de Dominicis, A. Laghi   +9 more
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Detection, attribution, and sensitivity of trends toward earlier streamflow in the Sierra Nevada [PDF]

, 2007
Observed changes in the timing of snowmelt dominated streamflow in the western United States are often linked to anthropogenic or other external causes.
Bonfils, Celine, Cayan, Daniel R., Duffy, Philip B., Maurer, Edwin P., Stewart-Frey, Iris T.   +4 more
core   +1 more source

Classification of COVID-19 patients from chest CT images using multi-objective differential evolution–based convolutional neural networks

European Journal of Clinical Microbiology and Infectious Diseases, 2020
Early classification of 2019 novel coronavirus disease (COVID-19) is essential for disease cure and control. Compared with reverse-transcription polymerase chain reaction (RT-PCR), chest computed tomography (CT) imaging may be a significantly more ...
Dilbag Singh, Vijay Kumar, Vaishali, Manjit Kaur   +3 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Diagnostic Performance of CT and Reverse Transcriptase-Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis

Radiology, 2020
Background Recent studies have suggested that chest computed tomography (CT) scans could be used as a primary screening or diagnostic tool for coronavirus disease 2019 (COVID-19) in epidemic areas.
Hyungjin Kim, Hyunsook Hong, S. Yoon
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source