Results 1 to 10 of about 461,186 (116)

DNA Condensation Triggered by the Synergistic Self-Assembly of Tetraphenylethylene-Viologen Aggregates and CT-DNA. [PDF]

Front Chem, 2021
Development of small organic chromophores as DNA condensing agents, which explore supramolecular interactions and absorbance or fluorescence-based tracking of condensation and gene delivery processes, is in the initial stages. Herein, we report the synthesis and electrostatic/groove binding interaction–directed synergistic self-assembly of the ...
Saraswathi SK, Karunakaran V, Maiti KK, Joseph J.   +3 more
europepmc   +5 more sources

Nicotiana glauca whole-genome investigation for cT-DNA study. [PDF]

BMC Res Notes, 2018
Nicotiana glauca (tree tobacco) is a naturally transgenic plant, containing sequences acquired from Agrobacterium rhizogenes by horizontal gene transfer. Besides, N. glauca contains a wide profile of alkaloids of medical interest.We report a high-depth sequencing and de novo assembly of N.
Khafizova G, Dobrynin P, Polev D, Matveeva T.   +3 more
europepmc   +5 more sources

HIBRID: Histology and ct-DNA based Risk-stratification with Deep Learning

AbstractBackgroundAlthough surgical resection is the standard therapy for stage II/III colorectal cancer (CRC), recurrence rates exceed 30%. Circulating tumor DNA (ctDNA) emerged as a promising recurrence predictor, detecting molecular residual disease (MRD). However, spatial information about the tumor and its microenvironment is not directly measured
Loeffler CM, Bando H, Sainath S, Muti HS, Jiang X, van Treeck M, Reitsam NG, Carrero ZI, Nishikawa T, Misumi T, Mishima S, Kotani D, Taniguchi H, Takemasa I, Kato T, Oki E, Yuan T, Wankhede D, Foersch S, Brenner H, Hoffmeister M, Nakamura Y, Yoshino T, Kather JN.   +23 more
europepmc   +2 more sources

Biological Effects of Low-Dose Chest CT on Chromosomal DNA [PDF]

Radiology, 2020
Background Although the National Lung Screening Trial reported a significant reduction in lung cancer mortality when low-dose (LD) CT chest examinations are used for a diagnosis, their biologic effects from radiation exposure remain unclear. Purpose To compare LD CT and standard-dose (SD) CT for DNA double-strand breaks and chromosome aberrations (CAs)
Hiroaki Sakane, Mari Ishida, Lin Shi, Wataru Fukumoto, Chiemi Sakai, Yoshihiro Miyata, Takafumi Ishida, Tomoyuki Akita, Morihito Okada, Kazuo Awai, Satoshi Tashiro   +10 more
openaire   +2 more sources

Intravenous Iodinated Contrast Agents Amplify DNA Radiation Damage at CT [PDF]

Radiology, 2015
To determine the effect of the use of iodinated contrast agents on the formation of DNA double-strand breaks during chest computed tomography (CT).This study was approved by the institutional review board, and written informed consent was obtained from all patients. This single-center study was performed at a university hospital.
Eike I, Piechowiak, Jan-Friedrich W, Peter, Beate, Kleb, Klaus J, Klose, Johannes T, Heverhagen   +4 more
openaire   +2 more sources

Naproxen Derivative Interaction Properties with ct-DNA

Hacettepe Journal of Biology and Chemistry, 2019
Interaction mode of a naproxen derivative (NH) with ct-DNA was explored by absorption and fluorescence spectroscopy. The experimental results revealed the static quenching as a result of groove binding between the naproxen derivative and ct-DNA. Computational studies were carried out to deeper understanding of the interactions.
Nuriye Akbay, Zeynep Koksal, Tugba Taskin-Tok, Ayse UZGOREN-BARAN   +3 more
openaire   +3 more sources

Detection of Chlamydia trachomatis DNA using MagNA Pure DNA extraction and Cobas Amplicor CT/NG amplification [PDF]

Clinical Microbiology and Infection, 2006
The automated MagNA Pure DNA extraction method for Chlamydia trachomatis was compared with the manual Cobas Amplicor protocol using 100 microL of input sample volume from 964 specimens. Agreement between protocols was 96.1%. The automated extraction method had a sensitivity of 99% and a specificity of 100%.
De Martino, S.J., de Barbeyrac, B., Piemont, Y., Barthel, C., Monteil, H., Jaulhac, B.   +5 more
openaire   +2 more sources

Study of CTS DNA Proficiency Tests with Regard to DNA Mixture Interpretation: A NIST Scientific Foundation Review

Genes, 2022
The National Institute of Standards and Technology has released a document entitled DNA Mixture Interpretation: A NIST Scientific Foundation Review for public comment. This has become known as the Draft NIST Foundation Review. It contains the statement: “Across these 69 data sets, there were 80 false negatives and 18 false positives reported from 110 ...
Bille, Todd, Coble, Michael D., Kalafut, Tim, Buckleton, John   +3 more
openaire   +2 more sources

Age-dependent differences in DNA damage after in vitro CT exposure

International Journal of Radiation Biology, 2018
Purpose: Age dependent radiation sensitivity for DNA damage after in vitro blood exposure by computer tomography (CT) was investigated. Materials and methods: Radiation biomarkers (dicentrics and gammaH2AX) in blood samples of newborns, children under five years and adults after sham exposure (0 mGy), low-dose (41 mGy) and high-dose (978 mGy) in vitro ...
Maria Gomolka, Ursula Oestreicher, Ute Rößler, Daniel Samaga, David Endesfelder, Peter Lang, Klement Neumaier, Claus Belka, Markus Niemeyer, Marion Kiechle, Uwe Hasbargen, Christoph Hübener, Hans-Joachim Kirlum, Ulrike Kulka, Albert Rosenberger, Linda Walsh, Sarah Baatout, Ausrele Kesminiene, Carita Lindholm   +18 more
openaire   +3 more sources

Interaction of ct-DNA with 2,4-Dihydroxy Salophen

Bulletin of the Korean Chemical Society, 2009
‒1 . The fluorescence study represents the quenching effect of 2,4-DHS on bound ethidium bromide to DNA. The quenching process obeys linear Stern-Volmer equation in extended range of 2,4-DHS concentration. Thermal denaturation experiments represent the increasing of melting temperature of DNA (about 3.5 o C) due to binding of 2,4-DHS. These results are
openaire   +2 more sources