Results 91 to 100 of about 11,382 (203)

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

open access: yesThe FEBS Journal, Volume 293, Issue 3, Page 749-765, February 2026.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner   +17 more
wiley   +1 more source

Cutaneous T-cell lymphoma in Saudi Arabia: retrospective single-center review

open access: yesAnnals of Saudi Medicine, 2017
BACKGROUND: Cutaneous T-cell lymphoma (CTCL) is an uncommon disease with various clinical presentations. The hypopigmented type is more common in individuals with a dark skin complexion.
Yousef Binamer
doaj   +1 more source

Efficacy of Narrowband UVB vs. PUVA in Patients with Early-Stage Mycosis Fungoides [PDF]

open access: yes, 2010
INTRODUCTION: Mycosis fungoides (MF) is a non-Hodgkin's T-cell lymphoma of the skin that often begins as limited patches and plaques with slow progression to systemic involvement.
Apetato, M, Ponte, P, Serrão, V
core   +1 more source

Medical Phototherapy Malpractice and Legal Precedents in North America (1983–2025)

open access: yes
International Journal of Dermatology, EarlyView.
Ghassan Barnawi   +6 more
wiley   +1 more source

Extracorporeal photopheresis—New insights into an old procedure

open access: yesTransfusion Medicine, Volume 36, Issue 1, Page 53-58, February 2026.
Abstract Background Extracorporeal photopheresis (ECP) is a safe immunomodulatory strategy that induces cell‐type selective apoptosis through photodynamic processes. Despite decades of use, the mechanisms underlying ECP remain largely unexplored, particularly in studies examining specific immune cell subsets in ex vivo setups.
Sabine Seiffert   +10 more
wiley   +1 more source

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer [PDF]

open access: yes, 2016
Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer ...
A Hayashi   +130 more
core   +1 more source

Targeting Phosphorylation of p21-activated Kinase 1 at Thr423 Induces Cell Cycle Arrest and Apoptosis in Cutaneous T-cell Lymphoma Cells

open access: yesActa Dermato-Venereologica, 2019
Cutaneous T-cell lymphoma (CTCL) represents a rare group of extranodal T-cell lymphoproliferative diseases. Due to poor clinical outcome of CTCL, there is an urgent need for new and improved therapies.
Yimeng Wang   +6 more
doaj   +1 more source

Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma

open access: yesThe Journal of Clinical Investigation, 2023
Our understanding of neuropathic itch is limited due to a lack of relevant animal models. Patients with cutaneous T cell lymphoma (CTCL) experience severe itching.
Ouyang Chen   +6 more
doaj   +1 more source

Prevalence of mycosis fungoides and its association with EBV and HTLV-1 in Pakistanian patients [PDF]

open access: yes, 2002
Mycosis fungoides (MF) is an indolent T cell lymphoma that is distinguished from other lymphomas by its initial appearance on the skin. The histologic diagnosis of MF may be difficult because there is significant overlap in the histologic features of ...
Moatter, Tariq   +4 more
core   +1 more source

Systemic therapy of cutaneous T-cell lymphoma (CTCL)

open access: yesChinese Clinical Oncology, 2019
Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous and relatively rare family of extranodal non-Hodgkin's lymphomas (NHL) that are primarily localized to the skin. Most patients present with cutaneous patches, plaques, tumors, more rarely with erythroderma. The type of skin lesions and the surface extent of skin involvement, as well as the presence
Onder, Alpdogan   +4 more
openaire   +2 more sources

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